خط مشی دسترسیدرباره ما
ثبت نامثبت نام
راهنماراهنما
فارسی
ورودورود
صفحه اصلیصفحه اصلی
جستجوی مدارک
تمام متن
منابع دیجیتالی
رکورد قبلیرکورد بعدی
library name : انستیتو تغذیه دانشگاه علوم پزشکی شهید بهشتی
Material Type : Latin Articles
Language of Document : English
Record Number : 61362
Doc. No : 11A
Main Entry : FOROUD A.
Title & Author : A DOUBLE-BLIND, PLACEBO-CONTROLLED PARALLEL TRIAL OF VITAMIN C TREATMENT IN MIDDLE AGED PATIENTS (35-50 YEARS OLD) WITH MILD PRIMARY HYPERTENSION [Article]
Title : IRANIAN HEART JOURNAL (IHJ)
Volume Number : , Vol.3-4 ؛ No.2-3
Date : , (2002)
page : : 49 - 53
Abstract : Objective: An evaluation of the effect of vitamin C on blood pressure is very important because hypertension is a major risk factor for cardiovascular, cerebral and renal diseases.We studied the effect of vitamin C on the blood pressure of patients between 35-50 years old with mild primary hypertension in Kerman.Methods: We conducted a prospective one-year double-blind, placebo controlled parallel trial on 42 middle aged patients with mild primary hypertension at the hypertension clinic in Kerman University of Medical Sciences. Following a 2-week run-in phase, two age and sex matched groups of untreated hypertensive subjects received 8 weeks oral treatment with either vitamin C, 250 mg twice daily )n=21; 8 M/13F, mean age 42.7▒آ5.3 years( or placebo one tablet twice daily )n=21; 10 M/IIF, mean age 42.7 ▒آ5.9 years(. Blood pressure was measured in the sitting position on three occasions during the run-in phase, and again at 1, 2, 4 and 8 weeks after commencing treatment. Venous blood samples for the measurement of plasma ascorbic acid were measured at baseline and at 1, 2, 4, 8 weeks after treatment.Results: Plasma ascorbic acid level in vitamin C group significantly changed from 8.8▒آ3 umol/l at baseline to 32.3▒آ12 umolll at 8 weeks, but in placebo-treated group, it changed from 13.8▒آ6 umolll at baseline to 9.01▒آ4.1 umolll at 8 weeks during the study period.A more significant fall in mean blood pressure was observed in the vitamin C group than the placebo-treated group such that the mean systolic blood pressure decreased from 153.1 ▒آ5 to 144▒آ5.3 mmHg in vitamin C group and from 154.1▒آ4.9 to 149▒آ4.9mmHg in the placebo group. The mean diastolic blood pressure decreased from 95.711.4 to 91.4▒آ1.7 mmHg in the vitamin C group and from 96.2▒آ1.6 to 94.0▒آ1.6 mmHg in the other group.At 8 weeks, the significant difference in the reduction of systolic blood pressure )p<0.05( and diastolic blood pressure )p<0.001( between the two groups became apparent. Conclusion: Vitamin C intake has a useful effect on lowering blood pressure.
Descriptor : SYSTOLIC BLOOD PRESSURE
Descriptor : DIASTOLIC BLOOD PRESSURE VITAMIN C
Descriptor : ANTIOXIDANT
Added Entry : FOROUD AFSAR
 
 
 
(در صورت عدم وضوح تصویر اینجا را کلیک نمایید)