خط مشی دسترسیدرباره ما
ثبت نامثبت نام
راهنماراهنما
فارسی
ورودورود
صفحه اصلیصفحه اصلی
جستجوی مدارک
تمام متن
منابع دیجیتالی
رکورد قبلیرکورد بعدی
library name : انستیتو تغذیه دانشگاه علوم پزشکی شهید بهشتی
Material Type : Latin Articles
Language of Document : English
Record Number : 61413
Doc. No : 63A
Main Entry : SAYAH M.
Title & Author : ANTICONVULSANT EFFECT OF FERULA GUMMOSA ROOT EXTRACT AGAINST EXPERIMENTAL SEIZURES [Article]
Title : IRANIAN BIOMEDICAL JOURNAL
Volume Number : , Vol.7 ؛ No.3
Date : , (2003)
page : : 139 - 144
Abstract : In Iranian traditional medicine, there are some reports regarding the anticonvulsantع‌ژ effect of Ferula gummosa Boiss. In this study, anticonvulsant activity, neurologicalع‌ژ deficits and lethality of the root acetone extract of this plant were evaluated in mice.ع‌ژ The extract exhibited dose-dependent prevention of tonic seizures induced byع‌ژ pentylenetetrazole )ED50 = 154.4 mg/kg(. However, the extract produced sedationع‌ژ and motor impairment with TD50 value of 546 mg/kg. Preliminary phytochemicalع‌ژ analysis showed the presence of terpenoids, alkaloids and a little amount ofع‌ژ cardenolids in the extract. It seems that the anticonvulsant and neurotoxic effects ofع‌ژ the extract is related in part to the terpenoid compounds. The acceptable protectiveع‌ژ index of the extract )3.5( recommends further studies on Ferula gummosa.ع‌ع
Descriptor : FERULA GUMMOSA
Descriptor : ANTICONVULSANT ACTIVITY; ROOT
Descriptor : ACETONE EXT
Added Entry : MANDEGARI A.
 
 
 
(در صورت عدم وضوح تصویر اینجا را کلیک نمایید)