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library name : انستیتو تغذیه دانشگاه علوم پزشکی شهید بهشتی
Material Type : Latin Articles
Language of Document : English
Record Number : 61414
Doc. No : 64A
Main Entry : ALI A
Title & Author : ANTICONVULSANT EFFECT OF SEED EXTRACT OF CAESALPINIA BONDUCELLA (ROXB.) [Article]; RAO N.V.,GOUDA SH.,SHANTAKUMAR S.M.
Title : IRANIAN JOURNAL OF PHARMACOLOGY AND THERAPEUTICS (IJPT)
Volume Number : , Vol.8 ؛ No.2
Date : , (2009)
page : : 51 - 55
Abstract : Objective: To study the Anticonvulsant activity of seed extract )petroleum ether( of Caesalpinia Bonducella )Roxb( Family- Ceasalpiniceae in mice.Background: In traditional system of Indian medicine C.bonducella is widely used for its antipyretic, antiperiodic, anticonvulsant and antiparalytic activities. The present study was aimed to explore the possible anticonvulsant and anxiolytic activities of seed extract of C.bonducella in experimental animals, mice.Methods: For assessing of anticonvulsant activity PTZ, MES, Strychnine, and Picrotoxin induced convulsions models were used. Diazepam was used as a standard reference for all models except MES; where-in Phenytoin was used as standard reference. Seed kernels of C. bonducella were powdered and subjected to successive extraction with solvents like petroleum ether )PE(, ethanol, methanol and water using soxhlet apparatus. All the extracts were administered as suspension in 2percent gum acacia in all the experiments.Results: Preliminary phytochemical investigation of the PECB )petroleum ether extract of caesalpinia bonducella( revealed the presence of saponins, glycoside, starch, sucrose, proteins, sterols and reported constituents like homoisoflavone )bonducillin( and a non alkaloid bitter principle )natin(. It was found to be non-toxic even upto the dose level of 3000mg/kg )LD50(. In PTZ, Strychnine and Picrotoxin induced convulsion models medium and high doses 600 and 800mg/kg but not the low dose 400mg/kg of PECB showed significant anti-convulsant activity by delaying the onset of convulsions and by increasing the latency of clonus and tonic-extensor convulsion. Anticonvulsant effect of high dose 800mg/kg was found to be better than the medium dose 600mg/kg(. In MES induced convulsion model medium and high doses 600 and 800mg/kg but not the low dose 400mg/kg of PECB had exhibited significant anticonvulsant effect by decreasing the duration of tonic-extensor phase and increasing the latency of clonus convulsion. Thus the result recorded with above experimental models confirms the anticonvulsant activity of PECB.Conclusion: The present investigation revealed that, the PECB possessed anticonvulsant activity. This activity profile of PECB may be contributed to the presence of phytoconstituents such as saponins, proteins, homoisoflavone )bonducillin(, carbohydrates and sterols present in the drug, as these are already reported for their anxiolytic and anti-convulsant activities.
Descriptor : C. BONDUCELLA
Descriptor : SEED KERNEL
Descriptor : PETROLEUM ETHER EXTRACT
Descriptor : ANTI-CONVULSANT ACTIVITY Printable Version
Added Entry : SHALAM M.D
: ASHFAQ M.D
 
 
 
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