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library name : انستیتو تغذیه دانشگاه علوم پزشکی شهید بهشتی
Material Type : Latin Articles
Language of Document : English
Record Number : 61416
Doc. No : 66A
Main Entry : HOSSEINZADEH H.,
Title & Author : ANTICONVULSANT EFFECTS OF CORIANDRUM SATIVUM L. SEED EXTRACTS IN MICE [Article]
Title : ARCHIVES OF IRANIAN MEDICINE
Volume Number : , Vol.3 ؛ No.4
Date : , (2000)
page : : 81 - 84
Abstract : Background-Coriander )vernacular Geshniz( seeds have been traditionally used in Iranian medicine for their carminative, diuretic and anticonvulsant effects.Objective-The anticonvulsant effects of the aqueous and ethanolic extracts of Coriandrum sativum seeds were studied in mice in order to evaluate the folkloric use of this plant. Methods-Two anticonvulsant evaluation tests, namely the pentylenetetrazole )PTZ( and the maximal electroshock tests, were used for assessing antiseizure effects.Results-In the pentylenetetrazole test, the aqueous and ethanolic extracts prolonged the onset of clonic convulsions and the anticonvulsant activity of high dose extracts )5 mg/kg( were similar to that of phenobarbital at a dose of 20 mg/kg in the PTZ test. Both extracts in high doses decreased the duration of tonic seizures and showed a statistically significant anticonvulsant activity in the maximal electroshock test.Conclusion-Results indicate that the aqueous and ethanolic extracts of C. sativum seeds may have a beneficial effect in petit mal and grand mal seizures.
Descriptor : CORIANDRUM SATIVUM
Descriptor : CORIANDER
Descriptor : ANTICONVULSANT ACTIVITY
Descriptor : MEDICINAL PLANTS
Descriptor : PENTYLENETETRAZOLE TEST
Added Entry : MADANIFARD M
 
 
 
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