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library name : انستیتو تغذیه دانشگاه علوم پزشکی شهید بهشتی
Material Type : Latin Articles
Language of Document : English
Record Number : 61426
Doc. No : 76A
Main Entry : RAO N.K.*
Title & Author : ANTI-HYPERGLYCEMIC AND RENAL PROTECTIVE ACTIVITIES OF ANDROGRAPHIS PANICULATA ROOTS CHLOROFORM EXTRACT [Article]
Title : IRANIAN JOURNAL OF PHARMACOLOGY AND THERAPEUTICS (IJPT)
Volume Number : , Vol.5 ؛ No.1
Date : , (2006)
page : : 47 - 50
Abstract : The chloroform extract of Andrographis paniculata roots was tested for its antihyperglycemic activity in alloxan induced diabetic rats using chronic and acute studies. Blood glucose levels were observed at does of 50, 100 and 150 mg/kg in acute study at various intervals. Where as in case of chronic study blood glucose levels, albuminuria, glycosuria and uremia were estimated after 4 weeks of treatment at the dose of 300 mg/kg. Significant reductions in blood glucose levels were observed in both acute and chronic studies. The extract significantly inhibited the induction of albuminuria, proteinemia and uremia. The resent study clearly indicated a significant antidiabetic activity with the chloroform extract of A. pani- culata roots and supports the traditional usage of the plant by Ayurvedic physicians for the control of diabetes. Also the extract is useful in preventing the incidence of long-term complication of diabetic nephropathy.
Descriptor : ALLOXAN
Descriptor : BLOOD GLUCOSE
Descriptor : RATS
Descriptor : ALBUMINURIA
Descriptor : PROTEINEMIA
Descriptor : UREMIA
 
 
 
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