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library name : انستیتو تغذیه دانشگاه علوم پزشکی شهید بهشتی
Material Type : Latin Articles
Language of Document : English
Record Number : 61428
Doc. No : 78A
Main Entry : RADJABIAN T
Title & Author : ANTI-HYPERLIPIDEMIC AND ANTI-ATHEROSCLEROTIC ACTIVITIES OF SILYMARINS FROM CULTIVATED AND WILD PLANTS OF SILYBUM MARIANUM L. WITH DIFFERENT CONTENT OF FLAVONOLIGNANS [Article]
Title : IRANIAN JOURNAL OF PHARMACOLOGY AND THERAPEUTICS (IJPT)
Volume Number : , Vol.9 ؛ No.2
Date : , (2010)
page : : 0 - 0
Abstract : To evaluate the influence of silymarins from cultivated and wild Silybum marianum L. plants with different content of flavonolignans, especially silibinin on serum lipids levels and also on the experimental atherosclerosis development in rabbits fed on high cholesterol-diet )HCD(. Fourthly males and six months aged white New Zealand rabbits )1.8-2 kg( were randomly assigned into five equal groups: control group - fed on HCD, and four groups fed on HCD and two different doses )100 and 200 mg/kg/day( of silymarins from cultivated and wild plants. Silymarin extracts were administered via the oral route, once daily for 2 months. Feeding of rabbits on HCD supplemented with both silymarins from cultivated and wild plants at the dose of 200 mg/kg/d caused a significant decrease in levels of total cholesterol, LDL-C and triacylglycerols. On the other hand, administration of silymarin from cultivated plants at the dose of 200 mg/kg/d in the diet enhanced significantly HDL-C serum content of rabbits. Both silymarins, at the dose of 200 mg/kg/d showed a significant inhibition of atherosclerotic plaque formation. Although a clear dose-dependent relationship was observed at the applied doses, but the pharmacological effects of silymarin from wild plants with lower content of silibinin, at the dose of 100 mg/kg/d were compared to those of silymarin of cultivated ones. Our results confirmed the anti-hyperlipidemic and anti-atherosclerotic effects of silymarin and also our findings suggest that other constituents than silybinin may be responsible for therapeutically effects of silymarin.
Descriptor : PHYLLANTHUS RHEEDII
Descriptor : ANTIHYPERGLYCEMIC
Descriptor : ANTIOXIDANT
Descriptor : ANTIHYPERLIPIDEMIC
Descriptor : STREPTOZOTOCIN
Added Entry : FALLAH HUSEINI H.
 
 
 
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