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library name : انستیتو تغذیه دانشگاه علوم پزشکی شهید بهشتی
Material Type : Latin Articles
Language of Document : English
Record Number : 61432
Doc. No : 82A
Main Entry : SAMBATH KUMAR R.*,
Title & Author : ANTIMICROBIAL AND ANTIOXIDANT ACTIVITIES OF CAREYA ARBOREA ROXB. STEM BARK [Article]; SIVAKUMAR P.,NETHAJI R.,GUPTA M.,MAZUMDAR U.K.
Title : IRANIAN JOURNAL OF PHARMACOLOGY AND THERAPEUTICS (IJPT)
Volume Number : , Vol.5 ؛ No.1
Date : , (2006)
page : : 35 - 41
Abstract : The present study was carried out to evaluate the antimicrobial and antioxidant activities of methanol extract of Careya arborea )MECA( stem barks )Myrtaceae( in various in-vitro systems. Antimicrobial activities of MECA were carried out using disc diffusion methods with Gram positive and Gram negative bacteria and some fungal species. MECA showed broad-spectrum antimicrobial activity against all tested microorganism Antioxidant and free radical scavenging activities of MECA was assessed by using 1,1-diphenyl-2-picryl-hydrazyl radical )DPPH(, superoxide anion radical, nitric oxide radical and hydroxyl radical scavenging assays. The antioxidant activity of MECA increased in a concentration dependent manner. In DPPH radical scavenging assay the IC50 value of the extract was found to be 132.25 ?g/mL. MECA was found to inhibit the nitric oxide radicals generated from sodium nitroprusside. The IC50 value was found to be 72.54 ?g/mL, whereas the IC50 value of curcumin was 20.4 ?g/mL. Moreover, the MECA was found to scavenge the superoxide generated by phenazine methosulphate )PMS( / nicotinamide adenine cleotide )NADH(-nitroblue tetrazolium )NBT( system. MECA was also found to inhibit the hydroxyl radical generated by Fentonعs reaction, where the IC50 value of MECA was found to be more than 1000إآ g/ml and for catechin the IC50 value was found to be 5 ?g/mL. The results obtained in the present study indicate that the MECA can be a potential source of natural antimicrobial and antioxidant agents.
Descriptor : CAREYA ARBOREA
Descriptor : ANTIMICROBIAL ACTIVITY
Descriptor : ANTIOXIDANT ACTIVITY
Descriptor : FREE RADICAL SCAVENGING
Descriptor : DPPH ASSAY
Added Entry : SIVAKUMAR TH
: SUNDERAM R.SH
 
 
 
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