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library name : انستیتو تغذیه دانشگاه علوم پزشکی شهید بهشتی
Material Type : Latin Articles
Language of Document : English
Record Number : 61458
Doc. No : 108A
Main Entry : GHARIB NASERI MOHAMMAD KAZEM
Title & Author : ANTISPASMODIC ACTIVITY OF ONION (ALLIUM CEPA L.) PEEL EXTRACT ON RAT ILEUM [Article]
Title : IRANIAN JOURNAL OF PHARMACEUTICAL RESEARCH (IJPR)
Volume Number : , Vol.7 ؛ No.2
Date : , (2008)
page : : 155 - 159
Abstract : Onion )Allium cepa( bulb from Liliaceae has antioxidant, spasmolytic and antihypertensive activities. The aim of present study was to investigate the antispasmodic effect of onion peel on rat ileum contractility. Onion peel powder was extracted by maceration in 70percent alcohol for 72 h. A terminal portion of ileum from male Wistar rat was dissected and its contractions were recorded isotonically in an organ bath containing Tyrode solution )37░آC( under 1 g tension. Extract cumulative concentrations )0.1, 0.2 and 0.4 mg/ml( reduced the ileum contractions induced by KCl )60 mM( and carbachol )10 mM( dose-dependently )P<0.0001(.The extract antispasmodic effect was not reduced by tissue incubation with propranolol )1 mM, 30 min(, naloxone )1 mM, 30 min(, L-NAME )100 mM, 20 min(, glibendamide )10 mM, 5 min( neither by tetraethylammonium )1 mM, 5 min(. In Ca2+-free with high K+)60 mM( Tyrode solution, extract reduced the ileum contractions induced by CaCl2 dose-dependently )P<0.05, P<0.01(. Onion peel extract inhibits ileum contractions without involving b-adrenoceptor, opioidreceptor, nitric oxide production, and potassium channels activation. It is suggested that quercetin in onion peel extract induces spasmolytic effect via calcium channels.
Descriptor : SPASMOLYTIC
Descriptor : ALLIUM CEPA PEEL
Descriptor : RAT
Descriptor : ILEUM
Added Entry : YAHYAVI H
: ARABIAN M
 
 
 
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