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library name : انستیتو تغذیه دانشگاه علوم پزشکی شهید بهشتی
Material Type : Latin Articles
Language of Document : English
Record Number : 61461
Doc. No : 111A
Main Entry : BOROUSHAKI M.T.
Title & Author : ANTITUSSIVE EFFECT OF PORTULACA OLERACEA L. IN GUINEA PIGS [Article]
Title : IRANIAN JOURNAL OF PHARMACEUTICAL RESEARCH (IJPR)
Volume Number : , Vol.3 ؛ No.3
Date : , (2004)
page : : 187 - 190
Abstract : Several therapeutic effects including diuretic, anti-pyretic and anti-scurvy have been - reported for Portulaca oleracea. In previous studies the analgesic, anti-inflammatory, antihypertensive, anti-oxidant, muscle relaxant effects and neuropharmacological effects of the, aqueous extract of Portulaca oleraceal1ave been demonstrated on experimental animals. In the present study the antitussive effect of this plant was evaluated. The antitusive effects of aerosols of two different concentrations of boiled extract, codeine: and saline were tested by. , counting the number of coughs induced by citric acid aerosol 10 min following exposure of animals. The effective concentration of extract causing 50percent reduction of cough number )EC50( was also determined. The results showed "significant reduction )p<0.001( in cough numbers following the use of both concentrations of the boiled extract )10.7 0.16 and 6.7 0.33 for percent2.5 and percent5 extracts respectively( compared to saline )14.8 0.30(. In addition there was a significant difference )p<0.01( between the cough numbers of the 5percent extract with that of codeine )10.2 0.38(. In this study, EC50 of the plant extract was 4.5percent. These results showed that the antitussive effect of Portulaca oleracea L. was comparable to codeine.
Descriptor : PORTULACA OLERACEA
Descriptor : ANTITUSSIVE EFFECT
Descriptor : MEDICINAL PLANTS
Descriptor : GUINEA PIG
Descriptor : CODEINE
Added Entry : BOSKABADI M.H.,
: MALEK F.
 
 
 
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