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library name : انستیتو تغذیه دانشگاه علوم پزشکی شهید بهشتی
Material Type : Latin Articles
Language of Document : English
Record Number : 61467
Doc. No : 117A
Main Entry : HEDAYATI S.M.,
Title & Author : APOLIPOPROTEIN E POLYMORPHISM IN AN IRANIAN HYPERCHOLESTROLEMIC POPULATION [Article]
Title : IRANIAN BIOMEDICAL JOURNAL
Volume Number : , Vol.6 ؛ No.4
Date : , (2002)
page : : 117 - 122
Abstract : Apolipoprotein E )apo E( is a structural constituent of several serum lipoprotein classes. It plays an important role in lipid metabolism by acting as a ligand for low-density lipoprotein )LDL( and chylomicron remnant receptors. Three common alleles called ?2, ?3 and ?4 have been described, which code for three protein isoforms )E2, E3 and E4(. The polymorphism is clinically significant, and it has therefore become very important in epidemiological studies attempting to obtain complete information about apo E allele frequencies in populations around the world. In the present study, two point mutations coding amino acid residues 112 and 158 were amplified using the polymerase chain reaction )PCR( from DNA extracted from 100 Iranian subjects. Apo E genotypes were determined by restriction fragment length polymorphism )RFLP( and allelic frequencies were estimated by gene counting )?2 = 0.01, ?3 = 0.88, ?4 = 0.11(. The Hardy-Weinberg expectation of genotype distribution was calculated from the estimated allele frequencies and ax2-test was used to test for equilibrium )x2 = 0.487, P>0.05(. Studentعs t-test indicated that subjects with the two most common apo E genotypes )E4/E4, E3/E3( were different from each other in means serum total cholesterol )t = 3.1, P<0.01(. Allele frequencies of the present study performed on Iranian subjects were similar to those of Japanese, Korean )Asian groups( Mexican and African American populations
Descriptor : APO E
Descriptor : POLYMORPHISM
Descriptor : PCR
Descriptor : GENETIC EPIDEMIOLOGY
Descriptor : LIPIDS
Added Entry : SAMADI A.
 
 
 
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