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library name : انستیتو تغذیه دانشگاه علوم پزشکی شهید بهشتی
Material Type : Latin Articles
Language of Document : English
Record Number : 61479
Doc. No : 129A
Main Entry : ENTEZARI MALIHEH
Title & Author : ASSESSMENT OF ANTIMUTAGENICITY AND ANTICANCER EFFECTS OF CITRUS LIMON [Article]; MEHRABIAN SEDIGHEH,HASHEMI MEHRDAD
Title : MEDICAL SCIENCES JOURNAL OF ISLAMIC AZAD UNIVERSITY
Volume Number : , Vol.18 ؛ No.2
Date : , (2008)
page : : 91 - 96
Abstract : Background: Currently cancer is considered as one of the main causes of mortality globally. Many chemicals in our environment can cause genetic mutations and are potentially responsible for millions of cancer-related deaths. The scientists are nowadays looking for food materials which can potentially prevent cancer occurrence. The aim of this research was to examine antimutagenicity and anticancer effects of Citrus Limon fruit juices.Material and methods: In the present study Human Astrocytoma cancer cells were cultured in DMEM )Gibco(, supplemented with 10percent fetal calf serum, penicillin, streptomycin, L-glutamine and incubated at 37oC for 2 days. In addition, cancer cell lines were treated by Citrus Limon fruit juice and cellular vital capacity was determined by MTT. The Citrus Limon fruit juice was subsequently evaluated in terms of antimutagenicity and anticancer properties by a standard reverse mutation assay )Ames Test(. For performing Ames Test salmonella typhimurium TA100 strain was chosen based on the fact that it had a specific mutation in the histidine operon, requiring histidine from a foreign source to ensure its growth. The mentioned strain gives rise to reverted colonies exposing to carcinogen substance )Sodium Azide(.Results: During MTT, human Astrocytoma cell line revealed to have a significant cell death when compared with controls )p<0.01(. In Ames Test the fruit juices prevented the reverted mutations and the hindrance percent of half-ripe Citrus Limon was 71.7percent and ripe Citrus Limon was 34.4percent in antimutagenicity test and this value in anticancer test was 83.3percent and 50percent in half-ripe Citrus Limon and ripe Citrus Limon, respectively.Conclusion: This is the first study that revealed antimutagenicity and anticancer effects of Citrus Limon fruit juice and the effects were higher in half-ripe Citrus Limon in comparison to the ripe one.
Descriptor : ANTIMUTAGENICITY
Descriptor : ANTICANCER
Descriptor : CITRUS LIMON
Descriptor : HUMAN ASTROCYTOMA CANCER CELLS
Descriptor : AMES TEST
Added Entry : MAJD AHMAD
: FALAHIAN F.A
 
 
 
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