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library name : انستیتو تغذیه دانشگاه علوم پزشکی شهید بهشتی
Material Type : Latin Articles
Language of Document : English
Record Number : 61492
Doc. No : 142A
Main Entry : GOZALPOUR E
Title & Author : ASSOCIATION BETWEEN ALZHEIMER عS DISEASE AND APOLIPOPROTEIN E POLYMORPHISMS [Article]; KHORAM KHOURSHID H.R.,OUHADI M.,KARIMLOU M.,MIRABZADEH A.,FOTOUHI A.*
Title : IRANIAN JOURNAL OF PUBLIC HEALTH
Volume Number : , Vol.39 ؛ No.2
Date : , (2010)
page : : 1 - 6
Abstract : Background: Alzheimerعs disease as a neurodegenerative disorder is the commonest type of dementia. A growing number of genes have been reported as the risk factors, which increase the susceptibility to Alzheimerعs disease. Apolipoprotein E )APOE(, which its !4 allele has been reported as a risk factor in late onset Alzheimerعs disease )AD(, is the main cholesterol carrier in the brain. The main goal of this study was to assess the role of APOE genotypes and alleles in AD in Iranian population. Methods: This study was performed in Tehran, Iran from 2007 to 2008. Totally, 154 AD cases and 162 control subjects from Iranian population were genotyped for APOE using PCR method. Genotype and alleles frequencies for APOE were calculated and compared between AD case and control subjects by 42 or Fisherعs exact test. Type one error assumed less than 0.05. Results: The frequency of e2e3 genotype was significantly higher in control subjects than AD patients was )13.5percent versus 5.2percent, P< 0.05( and e3e4 genotype frequency was significantly higher in AD cases compared with control subjects. APOE -e2 allele frequency in cases was lower than that of control subjects but this difference was not significant )4.2percent versus 7.7percent(. Conclusion: It seems that individuals carrying e4 allele, develop AD 6.5 times more than non-carriers do )OR= 6.566, 95percent CI= 2.89-14.92(. It has been reported that e4 allele acts in dose- age-dependent manner but we have shown that the risk of developing AD in male APOE -!4 allele carriers is higher than that of female !4 carriers.
Descriptor : ALZHEIMERع DISEASE
Descriptor : APOLIPOPROTEIN E
Descriptor : IRAN
Added Entry : KAMALI K
: MOHAMMAD K
 
 
 
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