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library name : انستیتو تغذیه دانشگاه علوم پزشکی شهید بهشتی
Material Type : Latin Articles
Language of Document : English
Record Number : 61493
Doc. No : 143A
Main Entry : MEHRABANI M
Title & Author : ASSOCIATION BETWEEN BLOOD DONATION FREQUENCY, ANTIOXIDANT ENZYMES AND LIPID PEROXIDATION [Article]; HAJIBEYGI B.,ZERAATI HOJAT,FATEHI F.,CHAMARI M.
Title : ACTA MEDICA IRANICA
Volume Number : , Vol.46 ؛ No.5
Date : , (2008)
page : : 361 - 366
Abstract : Iron is a pro-oxidant cofactor that may be linked to atherosclerosis progression. Free iron catalyzes the generation of free radicals and free radicals promote the oxidation of lipids. Reduction of body iron stores secondary to blood donation has been hypothesized to reduce lipid peroxidation. The aim of this study was to evaluate the association between blood donation and antioxidant enzymes and lipid peroxidation product malondialdehyde )MDA(. We investigated hemoglobin )Hb(, serum ferritin, MDA level, glutathione peroxidase )GPX( and superoxide dismutase )SOD( activities in the whole blood of 150 male volunteer blood donors aged from 30 to 60 years attending Tehran Blood Transfusion Center. Subjects were divided into 5 groups according to the frequency of blood donation per year. With increasing the number of blood donation in a year, the body iron stores, GPX activity and serum MDA level were significantly reduced )P < 0.05( but SOD activity was significantly increased )P < 0.05(. High-frequency blood donors had evidence of decreased body iron stores, decreased lipid peroxidation and enhanced activity of antioxidant enzymes when compared with low-frequency donors.
Descriptor : BLOOD DONATION
Descriptor : SUPEROXIDE DISMUTASE
Descriptor : GLUTATHIONE PEROXIDASE
Descriptor : FERRITIN
Descriptor : MALONDIALDEHYDE
Added Entry : JALALI M
: SADEGHI M.R
 
 
 
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