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library name : انستیتو تغذیه دانشگاه علوم پزشکی شهید بهشتی
Material Type : Latin Articles
Language of Document : English
Record Number : 61496
Doc. No : 146A
Main Entry : VEYSI RAIGANI A
Title & Author : ASSOCIATION BETWEEN ENZYMATIC AND NON-ENZYMATIC ANTIOXIDANT DEFENSE WITH ALZHEIMER DISEASE [Article]; NOUROUZIAN M.,POURMOTEABED A.R.
Title : ACTA MEDICA IRANICA
Volume Number : , Vol.45 ؛ No.4
Date : , (2007)
page : : 271 - 276
Abstract : The etiopathogenesis of Alzheimerعs disease )AD( is still unclear. However, long-term oxidative stress is believed to be one of the major contributing factors in progression of neuronal degeneration and decline of cognitive function in AD. In order to assess the presence of oxidative stress in AD, we examined the enzymatic activities of the erythrocyte Cu-Zn superoxide dismutase )Cu-Zn SOD(, glutathione peroxidase )GSH-Px(, catalase )CAT(, and plasma level of total antioxidant status )TAS( in AD and control groups )age and sex-matched(. The results showed that the Cu-Zn SOD activity was significantly higher and the level of GSH-Px and TAS activities were significantly lower in AD subjects than that in the control group )2111 ▒آ 324 U/grHb, 43.7 ▒آ 11.6 U/grHb, and 1.17 ▒آ 0.23 mmol/l compared with 1371 ▒آ 211 U/grHb; t= -2.17, P = 0.036, 56.3 ▒آ 9.5 U/grHb; t=3.8, P = 0.014, and 1.54▒آ0.2 mmol/l; t=11.18, P < 0.001, respectively(. While, the erythrocyte CAT activity was lower in AD subjects compared to the control group, the difference was not statistically significant )t = 1.3, P = 0.15(. These findings support the idea that the oxidative stress plays an important role in the pathogenesis underlying AD neurodegeneration. In addition, the enzymatic activity of the erythrocyte Cu-Zn SOD and GSH-Px and the plasma level of TAS can be used as a measure of the oxidative stress and a marker for pathological changes in the brain of patients with AD.
Descriptor : ALZHEIMERعS DISEASE
Descriptor : OXIDATIVE STRESS
Descriptor : SUPEROXIDE DISMUTASE
Descriptor : GLUTATHIONE PEROXIDASE
Descriptor : CATALASE
Descriptor : HYDROGEN PEROXIDE
Added Entry : RAHIMI Z
: ZAHRAEI M
 
 
 
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