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library name : انستیتو تغذیه دانشگاه علوم پزشکی شهید بهشتی
Material Type : Latin Articles
Language of Document : English
Record Number : 61567
Doc. No : 218A
Main Entry : AGHEL N
Title & Author : CHARACTERIZATION OF AN ANTI-DERMATOPHYTE CREAM FROM ZATARIA MULTIFLORA BOISS [Article]
Title : IRANIAN JOURNAL OF PHARMACEUTICAL SCIENCES
Volume Number : , Vol.3 ؛ No.2
Date : , (2007)
page : : 77 - 84
Abstract : Throughout the world, there has been an increasing incidence of fungal infections, and because of drug resistance and toxicity associated with long-term treatment with antifungal drugs search for new drugs to treat fungal infections is ongoing. The aim of this study was to evaluate the physicochemical properties and stability of creams containing different concentrations of Zataria multiflora extract as anti-dermatophyte preparations. First, the minimum inhibitory concentration )MIC( of methanolic extract of aerial parts of Z. multiflora was assayed against various dermatophytes by in vitro tube dilution technique )MIC=0.5percent(. To select the best cream formulation, one general formula of cleansing cream was considered and then corrected. The best base formula was chosen according to its monotonousness, straightness and external attractiveness. Formulations containing 1, 2 or 3percent of the plant extracts were prepared. Finally, a cream containing 10percent bees wax, 58.8percent liquid paraffin, 1.2percent hard paraffin, 5percent spermaceti, 1percent borax, 1.4percent tween 80, 0.15percent methyl paraben, 0.15percent lactic acid, 0.05percent propyl paraben, 2percent Zataria extract and water was chosen as the best formulation. The final product was a W/O cream with suitable appearance and desirable physicochemical stability.
Descriptor : CREAM
Descriptor : DERMATOPHYTE
Descriptor : MIC
Descriptor : ZATARIA MULTIFLORA
Added Entry : MOGHIMIPOUR E
: AMERI A.A.GH.
 
 
 
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