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library name : انستیتو تغذیه دانشگاه علوم پزشکی شهید بهشتی
Material Type : Latin Articles
Language of Document : English
Record Number : 61641
Doc. No : 292A
Main Entry : SADEGHI ALIABADI H.*
Title & Author : CYTOTOXIC EFFECT OF CONVOLVULUS ARVENSIS EXTRACTS ON HUMAN CANCEROUS CELL LINE [Article]
Title : RESEARCH IN PHARMACEUTICAL SCIENCES (RPS)
Volume Number : , Vol.3 ؛ No.1
Date : , (2008)
page : : 31 - 34
Abstract : It has been reported that several members of Convolvulaceae family such as Convolvulus arvensis possess cytotoxic activity on some tumor cell lines. Proteoglycan mixture, the water extract of C. arvensis with high molecular weight, has potent anti-angiogenesis and stimulating effects. In this study, arial parts of C. arvensis were collected and identified, and the cytotoxic effects of chloroform, ethylacetate and hydroalcoholic extracts on human tumor cell line )Hela( were determined. Different concentrations of the extracts were added to the cultured cells and incubated for 72 h. Cell survival was evaluated using MTT assay. The chloroform extract of C. arvensis at tested concentrations showed a comparable cytotoxic effect to taxol against Hela cell )15 vs. 12 mg/ml(. In conclusion, the higher cytotoxic activity seen with chloroform extract may be related to the presence of lipophilic glycosides as non-polar compounds extracted by chloroform.
Descriptor : CONVOLVULUS ARVENSIS
Descriptor : PROTEOGLYCAN MIXTURE
Descriptor : HELA
Descriptor : MTT ASSAY
Added Entry : GHASEMI N
: KOUHI M.
 
 
 
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