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library name : انستیتو تغذیه دانشگاه علوم پزشکی شهید بهشتی
Material Type : Latin Articles
Language of Document : English
Record Number : 61642
Doc. No : 293A
Main Entry : FEYZZADEH B
Title & Author : CYTOTOXIC EFFECT OF SAFFRON STIGMA AQUEOUS EXTRACT ON HUMAN TRANSITIONAL CELL CARCINOMA AND MOUSE FIBROBLAST [Article]; RAHIMI ALI REZA,BOROUK A.,DOUSTI H.
Title : UROLOGY JOURNAL
Volume Number : , Vol.5 ؛ No.3
Date : , (2008)
page : : 161 - 167
Abstract : Introduction: Saffron has been suggested to have inhibitory effects on tumoral cells. We evaluated the cytotoxic effect of aqueous extract of saffron on human transitional cell carcinoma )TCC( and mouse non-neoplastic fibroblast cell lines.Materials and Methods: Human TCC 5637 cell line and mouse fibroblast cell line )L929( were cultivated and incubated with different concentrations of aqueous extract of saffron stigma )50 mg/mL to 4000 mg/mL(. Cytotoxic effect of saffron was evaluated by morphologic observation and 3-)4,5- dimethylthiazol-2-yl(-2,5-diphenyltetrazolium bromide colorimetric assay after 24, 48, 72, and 120 hours in each cell line.Results: After 24 hours, morphological observations showed growth inhibitory effects at saffron extract concentrations higher than 200 mg/mL for L929 cells and at concentrations of 50 mg/mL to 200 mg/mL for the TCC cells. These changes became more prominent after 48 hours. However, significant growth inhibitory effects of the extract were shown at concentrations of 400 mg/mL and 800 mg/mL. Higher concentrations of saffron correlated inversely with cell population of both cell lines. Significant reduction of the survived cells was seen at concentrations of 400 mg/mL and 2000 mg/Ml for TCC and L929 cell lines, respectively. After 120 hours, decrease in the percentage of survived cells at higher concentrations of saffron extract was seen in both cell lines. At a concentration of 800 mg/mL, the survived L929 cells plummeted to less than 60percent after 120 hours, while no TCC cells survived at this time. No L929 cells survived at 2000 mg/mL.Conclusion: Saffron aqueous extract has inhibitory effects on the growth of both TCC 5637 and normal L929 cell lines. This effect is dose dependent.
Descriptor : CROCUS SATIVUS
Descriptor : ANTINEOPLASTIC AGENTS
Descriptor : TRANSITIONAL CELL CARCINOMA
Added Entry : TAVAKOL AFSHARI J
: RAKHSHANDEH H
 
 
 
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