خط مشی دسترسیدرباره ما
ثبت نامثبت نام
راهنماراهنما
فارسی
ورودورود
صفحه اصلیصفحه اصلی
جستجوی مدارک
تمام متن
منابع دیجیتالی
رکورد قبلیرکورد بعدی
library name : انستیتو تغذیه دانشگاه علوم پزشکی شهید بهشتی
Material Type : Latin Articles
Language of Document : English
Record Number : 61671
Doc. No : 322A
Main Entry : AKHBARDEH M.*
Title & Author : DIETARY-INDUCED OBESITY AND HYPOTHALAMIC INFERTILITY IN FEMALE DBA/2J MICE [Article]
Title : IRANIAN JOURNAL OF REPRODUCTIVE MEDICINE
Volume Number : , Vol.7 ؛ No.supp.
Date : , (2009)
page : : 0 - 0
Abstract : Introduction: The effects of diet and adiposity have been implicated in disturbances of female reproductive function.Materials and Methods: In an effort to better elucidate the relationship between obesity and female fertility, we analyzed the effect of increasing dietary fat content on body composition, insulin sensitivity, and pregnancy rates in two common inbred mouse strains, DBA/2J and C57BL/6J.Results: After 16 wk, females of both strains on the high fat diet developed glucose intolerance and insulin resistance, but only the female DBA/2J mice developed dietary-induced obesity and hyperleptinemia. The high fat diet was associated with more than a 60percent decrease in natural pregnancy rates of female DBA/2J mice, whereas the fertility of female C57BL/6J mice was unaffected. Despite developing a similar degree of obesity, insulin resistance, and hyperleptinemia, male DBA/2J mice did not manifest diminished fertility. Obese female DBA/2J mice achieved normal ovulatory responses and pregnancy rates after exogenous gonadotropin stimulation, suggesting their fertility defect to be central in origin. Real-time PCR quantification of hypothalamic cDNA revealed a 100percent upregulation of neuropeptide Y and a 50percent suppression of GnRH expression accompanied by a 95percent attenuation of leptin receptor type B expression in obese female DBA/2J mice.Conclusion: These findings suggest that obesityassociated hyperleptinemia, and not insulin resistance or increased dietary fat per se, gradually induces central leptin resistance, increases hypothalamic neuropeptide Y-ergic tone, and ultimately causes hypothalamic hypogonadism. The data establish high fat-fed female DBA/2J mice as a wild-type murine model of obesityrelated infertility.
Descriptor : DIETARY-INDUCED OBESITY
Descriptor : DBA/2J MICE
Descriptor : LEPTIN
 
 
 
(در صورت عدم وضوح تصویر اینجا را کلیک نمایید)