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library name : انستیتو تغذیه دانشگاه علوم پزشکی شهید بهشتی
Material Type : Latin Articles
Language of Document : English
Record Number : 61672
Doc. No : 323A
Main Entry : OSAREH SH
Title & Author : DIFFERENT DOSES OF ORAL FOLIC ACID FOR HOMOCYSTEINE-LOWERING THERAPY IN PATIENTS ON HEMODIALYSIS A RANDOMIZED CONTROLLED TRIAL [Article]; ASGARI MOZHGAN,FAROKHI FARHAT
Title : IRANIAN JOURNAL OF KIDNEY DISEASES (IJKD)
Volume Number : , Vol.3 ؛ No.4
Date : , (2009)
page : : 227 - 233
Abstract : Introduction: We compared the effect of higher and lower doses of folic acid compared to our routine daily dose on plasma homocysteine levels, in our hemodialysis patients.Materials and Methods: Eighty patients on hemodialysis receiving oral folic acid, 10 mg/d, were randomized to receive folic acid at either doses of 5 mg/d )group 1( or 15 mg/d )group 2( for 2 months. Plasma levels of total homocysteine were measured before and after the study period.Results: Hyperhomocysteinemia was seen in 75 patients )93.8percent( before, and in 37 patients of group 1 )92.5percent( and 39 of group 2 )97.5percent( after the study period. In group 1, a nonsignificant decrease occurred in plasma homocysteine level )29.67▒آ12.26 mmol/L to 27.78▒آ9.94 mmol/L, P=.30(, while in group 2, there was a significant decrease in homocysteine level )32.40▒آ9.76 mmol/L to 29.58▒آ9.62 mmol/L, P=.01(. Changes in homocysteine level correlated with its baseline level )r=-0.42, P<.001(. In both groups, significant reductions in homocysteine level were seen mostly in those patients with high baseline homocysteines.Conclusions: Routine folic acid supplementation of 10 mg/d could not normalize plasma homocysteine levels in most of our patients. Increasing folic acid dose made a statistically significant but clinically trivial decrease in homocysteine levels, and could not normalize homocysteine level in most patients. Patients with a higher baseline homocysteine level achieved a greater reduction, which may be explained by primary noncompliance of some patient. Further investigation of folic acid dosage is suggested.
Descriptor : HYPERHOMOCYSTEINEMIA
Descriptor : CARDIOVASCULAR DISEASES
Descriptor : FOLIC ACID
Descriptor : KIDNEY FAILURE
Descriptor : HEMODIALYSIS
Added Entry : SHAYAN MOGHADAM H
: SALIMI ASHRAF
 
 
 
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