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library name : انستیتو تغذیه دانشگاه علوم پزشکی شهید بهشتی
Material Type : Latin Articles
Language of Document : English
Record Number : 61673
Doc. No : 324A
Main Entry : KHODADADI I
Title & Author : DIFFERENTIAL EFFECTS OF LONG-CHAIN FATTY ACIDS AND CLOFIBRATE ON GENE EXPRESSION PROFILES IN CARDIOMYOCYTES [Article]
Title : ARCHIVES OF IRANIAN MEDICINE
Volume Number : , Vol.11 ؛ No.1
Date : , (2008)
page : : 42 - 49
Abstract : Background: The link between dietary fat and coronary heart disease has attracted much attention since the effect of long-chain fatty acids on gene transcription has been established. The aim of this study was to investigate the effects of long-chain fatty acids and clofibrate on Mrna levels of specific lipid metabolism-related genes and to determine their effects on global transcriptome levels in a cardiovascular cell-line.Methods: After culturing P19CL6 cells with long-chain fatty acids or clofibrate, the expression levels of heart-type fatty-acid binding protein and peroxisome proliferators-activated receptors )PPARa,b,g( were determined by reverse transcriptase-polymerase chain reaction. Additionally, global transcriptome profiles were compared using microarray analysis.Results: Long-chain fatty acids significantly increased the abundance of PPARa and PPARg. Moreover, microarray analysis showed that the effects of linoleic and a-linolenic acids, and clofibrate were similar but differed from those of palmitic and oleic acids.Conclusion: These findings show that cellular responses to polyunsaturated fatty acids differ from those observed with saturated and monounsaturated fatty acids.
Descriptor : CARDIOMYOCYTE
Descriptor : FATTY ACIDS
Descriptor : GENE
Descriptor : MICROARRAY
Added Entry : GRIFFIN B
: THUMSER A
 
 
 
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