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library name : انستیتو تغذیه دانشگاه علوم پزشکی شهید بهشتی
Material Type : Latin Articles
Language of Document : English
Record Number : 61702
Doc. No : 353A
Main Entry : KABOUDANIAN ARDESTANI S.,
Title & Author : EFFECT OF CIMETIDINE AND RANITIDINE ON LIPID PROFILE AND LIPID PEROXIDATION IN ?-IRRADIATED MICE [Article]; TAVAKOLI Z.
Title : ACTA MEDICA IRANICA
Volume Number : , Vol.42 ؛ No.3
Date : , (2004)
page : : 198 - 204
Abstract : Elevated amounts of free radicals due to ionizing radiation have damaging effects on the body. H2-receptor antagonists have potential oxygen radical scavenging properties. We tried to determine the effects of two H2-receptor antagonists )cimetidine and ranitidine( on lipid peroxidation )LPO( and lipid profile )LP( in plasma and liver of ?-irradiated )1Gy/day for 3 days( BALB/c mice. The control group of mice were fed with normal food and drinks but the experiment group of mice were fed control diet and drinking water, containing cimetidine or ranitidine )1mg/lit(. After 3 days of supplementation, the animals were subjected to sublethal ?-radiation, which caused a significant increase in cholesterol level in experimental group )100percent increase in comparison with the control group(, but the amount of phospholipids did not change. The ratio of cholesterol to phospholipid showed a slight increase. Also ?-irradiation caused a significant increase in lipid fluorescence )11-48percent(, conjugated dienes )33-81percent( in liver and increase in malondialdehyde )19-300percent( in serum of mice who had received 1.09-3.1 Gy for 1-3 days. Cimetidine or ranitidine supplementation was able to restore the changes of LPO and LP in mice )1 Gy-radiated for 3 days(. It is therefore concluded that the mice treated with cimetidine or ranitidine were able to tolerate biomembrane damages provoked by sublethal ?-radiation. This supports the hypothesis that cimetidine or ranitidine may afford an efficient protection against ionizing radiation or diseases that are characterized by in vivo free radical-mediated oxidative stress mechanisms.
Descriptor : ?
Descriptor : -IRRADIATION
Descriptor : BALB/C MICE
Descriptor : LIPID PROFILE
Descriptor : LIPID PEROXIDATION
Descriptor : H2-RECEPTOR ANTAGONIST
Added Entry : MAHMOOD JANLOW M
: KARIMINIA AMINA
 
 
 
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