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library name : انستیتو تغذیه دانشگاه علوم پزشکی شهید بهشتی
Material Type : Latin Articles
Language of Document : English
Record Number : 61703
Doc. No : 354A
Main Entry : FARHADI M
Title & Author : EFFECT OF DIFFERENT GLUCOSE CONCENTRATIONS ON PC12 CELLS APOPTOSIS: ROLE OF BAX AND BCL2 PROTEINSEFFECT OF DIFFERENT GLUCOSE CONCENTRATIONS ON PC12 CELLS APOPTOSIS: ROLE OF BAX AND BCL2 PROTEINS [Article]; ZEYNALI S.,MOUSAVI S.H.,BAKHSHAYESH M.
Title : MEDICAL SCIENCES JOURNAL OF ISLAMIC AZAD UNIVERSITY
Volume Number : , Vol.15 ؛ No.4
Date : , (2006)
page : : 161 - 166
Abstract : Background: In diabetics, hyperglycemia is associated with neuropathy, nephropathy, and retinopathy. However, direct toxic effects of glucose on neurons are still largely unknown.Materials and methods: Firstly, cellular vital capacity was determined by MTT. Then, effects of different glucose concentrations and the role of Bax protein-induced apoptosis in PC12 cells was examined by Hoechst staining and western blotting techniques, respectively.Results: During MTT, cells revealed to have a meaningful apoptosis at hours 48, 72, and 96 when compared with controls )p<0.01(. Apoptosis was induced suitably at a glucose concentration of 13.5mg/dl after 72 hours. Western blotting showed a significant expression of Bax protein in PC12 cells treated with increased glucose concentrations for 72 hours.Conclusion: Increment in glucose concentration may induce apoptosis in PC12 cells. This process occurred under the intense influence of Bax protein.
Descriptor : GLUCOSE TOXICITY
Descriptor : APOPTOSIS
Descriptor : PC12 CELL
Descriptor : BAX PROTEIN
Added Entry : PARIVAR KAZEM
: SHARIFI A.M
 
 
 
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