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library name : انستیتو تغذیه دانشگاه علوم پزشکی شهید بهشتی
Material Type : Latin Articles
Language of Document : English
Record Number : 61710
Doc. No : 361A
Main Entry : MOHAMMADZADEH A.
Title & Author : EFFECT OF HIGH VERSUS LOW DOSES OF HUMAN RECOMBINANT ERYTHROPOIETIN ON THE ANEMIA OF PREMATURITY [Article]
Title : ACTA MEDICA IRANICA
Volume Number : , Vol.43 ؛ No.2
Date : , (2005)
page : : 95 - 98
Abstract : Recombinant human erythropoietin )rh-EPO( is known to accelerate erythropoiesis in preterm infants. The purpose of this study was to compare the effectiveness of early treatment with two doses of rh-EPO )high vs. low dose( in the management of anemia of prematurity. Twenty preterm infants with hematocrit )Hct( < 30percent when infantعs age was between 2 to 3 weeks after birth or Hct < 25percent when infantعs age was more than 3 weeks after birth, were divided randomly in two groups, each group including 10 babies. Infants in high dose group received 500 u/kg rh-EPO twice per week and the low dose group received 500 u/kg rh-EPO weekly. All infants were fed human milk supplemented with enteral iron. Hematocrit and reticulocyte counts were determined for each infant at the start of the study, 3 days after start of treatment and one week after the end of treatment. The means of gestational age in high dose and low dose groups were 31.4 ▒آ 2.2 and 31.3▒آ2.0 weeks, respectively. Means of birth weight in high dose and low dose groups were 1366 ▒آ 243 and 1438▒آ249 gr, respectively. The two groups were significantly different in reticulocyte count at 3 days after treatment )P = 0.047( and in hematocrit at the end of study )P < 0.0001(. We concluded the early treatment of anemia of prematurity with high dose rh-EPO with supplemental iron significantly increases hematocrit and reticulocyte in preterm infants and reduce the need for blood transfusion in these high risk neonates
Descriptor : ERYTHROPOIETIN
Descriptor : ANEMIA
Descriptor : PREMATURITY
Descriptor : NEONATE
Added Entry : NASERI F.
 
 
 
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