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library name : انستیتو تغذیه دانشگاه علوم پزشکی شهید بهشتی
Material Type : Latin Articles
Language of Document : English
Record Number : 61719
Doc. No : 371A
Main Entry : HOSSEINZADEH H.
Title & Author : EFFECT OF NEPETA GLOMERULOSA BOISS. AERIAL PARTS AQUEOUS EXTRACT ON MORPHINE WITHDRAWAL SYNDROME IN MICE [Article]
Title : IRANIAN JOURNAL OF PHARMACEUTICAL SCIENCES
Volume Number : , Vol.2 ؛ No.1
Date : , (2006)
page : : 41 - 46
Abstract : The effect of aqueous extract of Nepata glomerulosa Boiss. aerial parts on morphine withdrawal syndrome was investigated in mice. Dependence was induced by subcutaneous injections of morphine for 3 consecutive days. On day 4, morphine was injected 2 h prior to intraperitoneal injection of naloxone. The number of jumps during a 20 min. period after naloxone injection was considered as a measure of the withdrawal syndrome. Open field and rotarod tests were also performed. The results indicated that the aqueous extract )0.1 to 2.8 g/kg, s.c.( and diazepam )5 mg/kg( reduced the number of jumps )58▒آ2.3 to 10▒آ0.82, p<0.001 vs normal saline, 87▒آ3.4(. The extracts also reduced motion balance and locomotion activity. It is concluded that the aqueous extract of N. glomerulosa aerial parts could diminish morphine withdrawal syndrome.
Descriptor : HORSERADISH PEROXIDASE
Descriptor : MERCURIC CHLORIDE
Descriptor : ENZYME INHIBITION
Descriptor : O DIANISIDINE
Added Entry : ZIAEE T.
 
 
 
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