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library name : انستیتو تغذیه دانشگاه علوم پزشکی شهید بهشتی
Material Type : Latin Articles
Language of Document : English
Record Number : 61757
Doc. No : 410A
Main Entry : NAJAFI MOSLEM
Title & Author : EFFECTS OF L-CARNITINE ON CARDIAC APOPTOSIS IN ISCHEMIC- REPERFUSED ISOLATED RAT HEART [Article]
Title : IRANIAN JOURNAL OF PHARMACEUTICAL SCIENCES
Volume Number : , Vol.3 ؛ No.1
Date : , (2007)
page : : 19 - 24
Abstract : Carnitine is a vital biologic substance for transporting fatty acids into myocytes. It also facilitates fatty acids b-oxidation for energy production. In this study, effects of L-carnitine )L-Car( on apoptosis in the ischemic isolated rat heart were investigated. Male Sprague-Dawley rats were divided into four groups and anesthetized by sodium pentobarbital. The heart was removed and mounted on a Langendorff apparatus then perfused by a modified Krebs-Henseleit )K/H( solution under a constant pressure at 37░آC. In the control group, the hearts were perfused only by normal K/H solution at stabilization, 30 min. regional ischemia and 120 min. reperfusion, while in each of the test groups, the hearts were perfused during ischemia-reperfusion with 0.5, 2.5 and 5 mM of L-Car-enriched K/H solution, respectively. At the end of reperfusion, immunohistochemical detection of apoptotic cells was performed by using an in situ apoptosis detection kit. The number of TUNEL-positive cardiomyocytes was counted in five random high-power fields in each sample. In the control group, the number of apoptotic cells were 48▒آ3 while addition of L-Car )0.5, 2.5 and 5 mM( to the solution reduced the number of apoptotic cells to 6▒آ1, 4▒آ1 and 3▒آ1, respectively )p<0.001 for all concentrations(. There was no significant difference between and within test groups using ANOVA one-way. Considering these results, we conclude that L-Car has a protective effect against cardiac ischemia-reperfusion induced injuries as a reduction of apoptotic cardiomyocytes.
Descriptor : APOPTOSIS
Descriptor : ISOLATED HEART
Descriptor : L-CARNITINE
Descriptor : RAT
Added Entry : GARJANI A.R
: DOUSTAR Y
 
 
 
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