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library name : انستیتو تغذیه دانشگاه علوم پزشکی شهید بهشتی
Material Type : Latin Articles
Language of Document : English
Record Number : 61759
Doc. No : 412A
Main Entry : ALIYALI M
Title & Author : EFFECTS OF N-ACETYLCYSTEINE ON ASTHMA EXACERBATION [Article]; ZALI F.
Title : IRANIAN JOURNAL OF ALLERGY, ASTHMA AND IMMUNOLOGY (IJAAI)
Volume Number : , Vol.9 ؛ No.2
Date : , (2010)
page : : 103 - 109
Abstract : Airway mucus hypersecretion and increased oxidative stress are clinical and pathophysiological features of asthma exacerbation. We studied effects of N-acetylcysteine )NAC( as a mucolytic and antioxidant agent in asthma exacerbation.In this randomized, single-blinded, placebo-controlled study 50 patients ) 17 male, 33 female, mean age 48.94▒آ13.68( with asthma exacerbation were randomized to receive either oral 600 mg b.d. N-acetylcystiene or placebo in addition to standard treatment during 5 days hospitalization. Daily measurements of wheezing, dyspnea, cough, sputum, expectoration, night sleep scores and morning PEFR were performed.There was no significant difference in wheezing score between patients assigned NAC and those assigned placebo in day 5)0.84[SD 0.94[ VS 0.87[SD 0.79[( and also in cough score )0.72[SD 0.84[ VS 0.79[SD 0.97[(, dyspnea score )0.84[SD 1.06[ VS 0.91[SD 1.01[(, sputum score)0.79[SD 0.83[ VS 0.62[SD 0.71[(, expectoration score)0.79[SD 0.97[ VS 0.83[SD 1.09[(, night sleep score)1[SD 1.17[ VS 0.67[SD 0.98[ and morning PEFR )256[SD 96.36[ VS 282[SD 98.86[(.We concluded that addition of N-acetylcysteine to usual asthma medication has no significant effect in treatment of asthma exacerbation.
Descriptor : ANTIOXIDANT
Descriptor : ASTHMA
Descriptor : MUCUS HYPERSECRETION
Descriptor : MUCOLYTIC
Descriptor : N-ACETYLCYSTEINE
Added Entry : POURHASAN AMIRI A
: SHARIFPOUR ALI
 
 
 
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