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library name : انستیتو تغذیه دانشگاه علوم پزشکی شهید بهشتی
Material Type : Latin Articles
Language of Document : English
Record Number : 61762
Doc. No : 415A
Main Entry : SHAMS J
Title & Author : EFFECTS OF PAPAVER RHOEAS EXTRACT ON THE TOLERANCE DEVELOPMENT TO ANALGESIC EFFECTS OF MORPHINE IN MICE [Article]; SALIMI S.H.,FATEMI S.M.,POUR MATABED A.,GHOSHOUNI H.,KAMALINEZHAD M.
Title : IRANIAN JOURNAL OF PHARMACEUTICAL RESEARCH (IJPR)
Volume Number : , Vol.7 ؛ No.2
Date : , (2008)
page : : 141 - 147
Abstract : Previous studies have shown that the extract of Papaver rhoeas reduces morphine dependence, locomotor activity and reward. In present study, the effects of hydro-alcohol extract of Papaver Rhoeas on the tolerance to analgesic effects of morphine in mice have been investigated using tail flick method. Subcutaneous )s.c.( administration of morphine )1, 2, 5 and 10 mg/kg( induced analgesia. However, intrapretoneal administration of the hydro-alcohol extract of Papaver rhoeas )25, 50 and 100 mg/kg( had not an effects on analgesia. Reduction of analgesic in mice pretreated with morphine )50 mg/kg, twice daily; for 3 days(, alone, indicated that tolerance has been developed. Hydro-alcohol extract of Papaver rhoeas )25, 50 and 100 mg/kg, i.p.( administration, 30 min before each of three daily doses of morphine, attenuated the morphine tolerance dose-independently, indicating that administration of the extract reduces morphine tolerance in mice.
Descriptor : PAPAVER RHOEAS
Descriptor : MORPHINE
Descriptor : ANALGESIA
Descriptor : TOLERANCE
Descriptor : MICE
Added Entry : SAHRAEI HEDAYAT
: FAGHIH MONZAVI Z
 
 
 
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