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library name : انستیتو تغذیه دانشگاه علوم پزشکی شهید بهشتی
Material Type : Latin Articles
Language of Document : English
Record Number : 61764
Doc. No : 417A
Main Entry : MOHAMED ESSA M.M
Title & Author : EFFECTS OF PONGAMIA PINNATA ON LIPID PEROXIDATION PRODUCTS AND ANTIOXIDANTS IN HYPERAMMONEMIC RATS: WITH REFERENCE TO CIRCADIAN VARIATIONS [Article]
Title : IRANIAN JOURNAL OF PHARMACOLOGY AND THERAPEUTICS (IJPT)
Volume Number : , Vol.6 ؛ No.2
Date : , (2007)
page : : 119 - 123
Abstract : Effects of Pongamia pinnata, an indigenous plant used in Ayurvedic Medicine in India on the temporal variations of circulatory lipid peroxidation products and antioxidants in ammonium chloride-)AC(-induced hyperammonemic rats has been studied. Experimental rats were divided into control, AC-treated, those treated with AC + ethanolic leaf extract of P. pinnata )PPEt(, and PPEt-treated. The characteristics of 24 h rhythms )acrophase, amplitude and mesor( of lipid peroxidation products )thiobarbituric acid reactive sub stances - TBARS( and antioxidants )reduced glutathione )GSH(, glutathione peroxidase )GPx(, superox ide dismutase )SOD( and catalase )CAT(( were analyzed. Elevated lipid peroxidation )increased mesor of TBARS( associated with decreased activities of antioxidants )decreased mesor of GPx, GSH, SOD and CAT( were found in hyperammonemic rats. Differences were also found in amplitude and 'r' values between the hyperammonemic rats and other experimental groups. These alterations clearly indicate that temporal redox status could be modulated by PPEt during hyperammonemic conditions, which may also play a crucial role in disease development.
Descriptor : HYPERAMMONEMIA
Descriptor : PONGAMIA PINNATA
Descriptor : CIRCADIAN
Descriptor : LIPID PEROXIDATION
Descriptor : ANTIOXIDANTS
Added Entry : SUBRAMANIAN P.*
 
 
 
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