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library name : انستیتو تغذیه دانشگاه علوم پزشکی شهید بهشتی
Material Type : Latin Articles
Language of Document : English
Record Number : 61772
Doc. No : 425A
Main Entry : MIRJAVADI S.A.R
Title & Author : EFFICACY OF THE KETOGENIC DIET AS A THERAPY FOR INTRACTABLE EPILEPSY IN CHILDREN [Article]; AZARGASHB E.A.,ABD ELAH GORJI F.,GHOFRANI MOHAMMAD
Title : IRANIAN JOURNAL OF CHILD NEUROLOGY (IJCN)
Volume Number : , Vol.4 ؛ No.2
Date : , (2010)
page : : 27 - 36
Abstract : Objective: To determine the role of ketogenic diet in the treatment of intractable epilepsy in children.Materials & Methods: Sixty six consecutive children )1-16 years old( with intractable epilepsy whose seizure were not neurodegenerative nor febrile in origin were recruited. They received the ketogenic diet and we evaluated its effect on seizure frequency for 3 months. All these children had more than five seizures per week despite adequate therapy with at least 3-4 anticonvulsant medications. Carbohydrates were initially limited to 10 gr/day and fats constituted 75percent of the total energy requirement. Response to the diet was categorized as free of seizure, 99percent-75percent, 50percent-75percent, 25percent-49percent and lower than 25percent reduction )resistant to therapy(.Results: Fifty five patients )84percent( out of 66 children initiating the diet continued it after 1 week. After 3 months, 80percent of the patients kept the diet. After one week, one month and 3 months, there was a more than 50percent decrease in the frequency of the seizures in 40 )60percent(, 50 )75percent( and 39 )59percent( of the patients, respectively. Three patients )4.5percent( were seizure-free after 1 week, 12 )18percent( were seizure-free after one month and 12 )18percent( were seizure-free after three months and a significant relationship was found between seizure reduction and the type of epilepsy )p<0.017(. Conclusion: The ketogenic diet should be considered as an alternative therapy for children with intractable seizures. It is more effective than many of the new anticonvulsant medications and is well tolerated by children and their families.
Descriptor : EPILEPSY
Descriptor : KETOGENIC DIET
Descriptor : CHILDREN
Added Entry : TONEKABONI S.H
: GHAZAVI M.R
 
 
 
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