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library name : انستیتو تغذیه دانشگاه علوم پزشکی شهید بهشتی
Material Type : Latin Articles
Language of Document : English
Record Number : 61788
Doc. No : 441A
Main Entry : AMARAPURKAR D.N
Title & Author : EVALUATING RISK FACTORS FOR DEVELOPMENT OF NON-ALCOHOLIC STEATOHEPATITIS IN TYPE-II DIABETES MELLITUS [Article]
Title : HEPATITIS MONTHLY
Volume Number : , Vol.8 ؛ No.3
Date : , (2008)
page : : 197 - 200
Abstract : Background and Aims: Non-alcoholic steatohepatitis )NASH( is reported to be present in 49-86percent of patients with type-II diabetes mellitus )DM(. Risk factors for the development of NASH in DM are not clear. This prospective analysis was planned to define the chronological relation between DM and NASH as well as to define risk factors for the development of NASH in DM.Methods: In a 3-year study, all consecutive NASH patients )n=100, age= 42.8▒آ4.6 years, M: F=4.2:1( were evaluated for the presence of DM, at baseline and during three monthly follow-up. In NASH patient with DM )group A, n=27, age=39.3▒آ5.2 years, M: F=4.4:1(, risk factors such as obesity, central obesity, dyslipidemia and family history of chronic liver disease were evaluated for comparative analysis. Similar number of consecutive patients of DM without evidence of liver disease )group B, n=27, age=45.9▒آ5.6 years, M: F=3:1( were analyzed for similar parameters.Results: Among 100 patients with NASH, 27 )27percent( patients had DM of whom, DM was preexisting in 13 )48.1percent(, was diagnosed at baseline in 11 )40.7percent( and was diagnosed during follow-up in 3 )11.1percent( patient. On statistical analysis )group A vs. group B(, none of the risk factors were found to be statically significant: obesity )77.7percent vs. 70.3percent(, central obesity )88.8percent vs. 92.5percent(, dyslipidemia )51.8percent vs. 44.4percent(, hypolipoproteinemia )7.4percent vs. 3.7percent(, family history of chronic liver disease )7.4percent vs. 0percent(, family history of DM )62.9percent vs. 66.6percent(, hypertension )18.5percent vs. 14.8percent(, ischemic heart disease )7.4percent vs. 11.1percent(, cerebrovascular disease )3.7percent vs. 0percent( and hyperuricemia )11.1percent vs. 14.8percent(.Conclusions: DM does not always precede NASH, but may follow NASH in some patients. Risk factors like obesity, central obesity, dyslipidemia and family history do not predict the development of NASH in diabetic patients.
Descriptor : TYPE-II DIABETES MELLITUS
Descriptor : NON-ALCOHOLIC STEATOHEPATITIS
Descriptor : CHRONIC LIVER DISEASE
Added Entry : PATEL N.D
: KAMANI P.M
 
 
 
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