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library name : انستیتو تغذیه دانشگاه علوم پزشکی شهید بهشتی
Material Type : Latin Articles
Language of Document : English
Record Number : 61791
Doc. No : 444A
Main Entry : ANNAMALAI P
Title & Author : EVALUATION OF ANALGESIC POTENTIAL OF SOLANUM TRILOBATUM ROOTS [Article]
Title : IRANIAN JOURNAL OF PHARMACEUTICAL RESEARCH (IJPR)
Volume Number : , Vol.8 ؛ No.4
Date : , (2009)
page : : 269 - 273
Abstract : In the present work, the antinociceptive action was assayed in several experimental models in mice: writhing, formalin and hot plate tests. The crude alkaloid fraction )25, 50, 100 mg/kg( and in a dose-dependent manner significantly reduced the nociception by acetic acid intTaperitoneal injection )P<0.00 I(. In the formalin test, the extract )50 and 100 mg/kg( also significantly reduced the painful stimulus in both phases of the test )P<0.001(. Treatment with the extract )25, 50, 100 mg/kg( when given i.p. or pentazocine )5 mg/kg, s.c.( produced a significant increase of the reaction time in hot plate test. These result showed that the alkaloid extract of Solanum trilobatum contains active analgesic principles acting both centrally and peripherally.
Descriptor : ANALGESIC
Descriptor : CRUDE ALKALOIDAL FRACTION
Descriptor : SOLANUM TRILOBATUM
Added Entry : KHOSA R.L
: HEMALATHA S
 
 
 
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