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library name : انستیتو تغذیه دانشگاه علوم پزشکی شهید بهشتی
Material Type : Latin Articles
Language of Document : English
Record Number : 61832
Doc. No : 486A
Main Entry : MOSTAFAVI SAYED ABOU ALFAZL
Title & Author : EXCRETION OF ACEBUTOLOL AND ITS MAJOR METABOLITE DIACETOLOL INTO INFANT BLOOD CIRCULATION AND THE BREAST MILK [Article]
Title : IRANIAN JOURNAL OF PHARMACEUTICAL RESEARCH (IJPR)
Volume Number : , Vol.2 ؛ No.3
Date : , (2003)
page : : 141 - 144
Abstract : Acebutolol )AC( is a chiral b-adrenergic blocking drug, which is useful clinically as the racemate in treating hypertension and is metabolized to an equipotent chiral metabolite, diacetolol )DC(. In this paper we report a case of a 32 year old woman who was receiving AC during her pregnancy and lactating time for management of hypertension. The maternal plasma level and breast milk as well as cord blood collected to see whether the drug is transferred to the fetus through the mother stereoselectively. A stereospecific high-performance liquid chromatographic )HPLC( assay was used to measure the enantiomeric concentrations of AC and DC. AC and DC enantiomers are stereoselectively excreted into the milk, although the concentrations of DC enantiomers were higher than those of AC. AC concentrations were very low in both cord artery and vein samples four hours after taking the drug however, the stereoselective concentrations of metabolite, DC, was found in these samples. In conclusion, AC and DC enantiomers are excreted in human breast milk in concentrations much higher than that in maternal plasma. Furthermore, DC was found in the infantعs plasma indicating that accumulation of metabolite did occur in this infant.
Descriptor : ACEBUTOLOL
Descriptor : DIACETOLOL
Descriptor : ENANTIOMERS
Descriptor : MILK
Descriptor : INFANT
Added Entry : STINSON D.A.,DOOLY K.,
: JAMALI KOHNE SHAHRI F
 
 
 
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