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library name : انستیتو تغذیه دانشگاه علوم پزشکی شهید بهشتی
Material Type : Latin Articles
Language of Document : English
Record Number : 61850
Doc. No : 504A
Main Entry : CHANDA R
Title & Author : FORMULATION DEVELOPMENT OF ORAL MUCOADHESIVE COATED TERBUTALINE SULPHATE TABLETS USING SOME NATURAL MATERIALS EXTRACTED FROM EDIBLE FRUITS AVAILABLE IN INDIA [Article]
Title : IRANIAN JOURNAL OF PHARMACEUTICAL SCIENCES
Volume Number : , Vol.5 ؛ No.1
Date : , (2009)
page : : 3 - 12
Abstract : Mucoadhesive polymers that bind to the gastric mucin or epithelial cell surface are useful in drug delivery for the purpose of increasing the intimacy and duration of contact of drug with the absorbing membrane. Several synthetic polymers are in use for this purpose. Since the biodegradability of the synthetic polymers are questionable, in this investigation, an oral mucoadhesive controlled delivery system has been developed for terbutaline sulphate using natural mucoadhesive materials extracted from edible fruits like Zizyphus mauritiana and Aegle marmelos that have better mucoadhesive property than synthetic polymer hydroxypropylmethylcellulose K4M )HPMCK4M(. The in vitro adhesive and mucoadhesive strength and swelling property of mucoadhesive materials extracted from edible fruits of Z. mauritiana and A. marmelos were evaluated and compared with HPMCK4M by Share stress and Wilhelmy plate method. Different formulations of oral mucoadhesive coated terbutaline sulphate tablets were prepared using these natural materials and HPMCK4M and hardness, thickness, friability, weight variation and assay of tablets were tested. The in vitro release of terbutaline sulphate was studied in buffer pH 7.2 at 37▒آ0.5░آC. The blood plasma concentration of terbutaline sulphate in rabbits was determined using HPLC. It was found that mucoadhesive materials extracted from edible fruits of Z. mauritiana and A. marmelos exhibited better adhesiveness and mucoadhesiveness as compared with the synthetic mucoadhesive agent HPMCK4M by ifferent methods. The in vitro and in vivo drug release study of terbutaline sulphate exhibited extended drug release profile for tablets prepared with natural materials than synthetic polymers. After in vitro and in vivo correlation study, it was seen that both in vitro and in vivo drug release study showed the same release profile. The present study shows that natural mucoadhesive materials extracted from edible fruits of Z. mauritiana and A. marmelos have greater mucoadhesive property than HPMCK4M where both are used in the same amount.
Descriptor : AEGLE MARMELOS
Descriptor : FORMULATION
Descriptor : HPMC
Descriptor : MUCOADHESION
Descriptor : NATURAL MATERIAL
Descriptor : TERBUTALINE
Descriptor : ZIZYPHUS MAURITIANA
Added Entry : NATH L.K
: MAHAPATRA S.
 
 
 
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