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library name : انستیتو تغذیه دانشگاه علوم پزشکی شهید بهشتی
Material Type : Latin Articles
Language of Document : English
Record Number : 61918
Doc. No : 573A
Main Entry : NEZHAD SHAHROKHABADI KH
Title & Author : STUDY OF CYTOTOXICITY EFFECT OF TOTAL SAFFRON EXTRACT ON HEPATOCARCINOMA CELL LINE (HEPG2) [Article]; BOROUK A.
Title : MEDICAL SCIENCES JOURNAL OF ISLAMIC AZAD UNIVERSITY
Volume Number : , Vol.19 ؛ No.3
Date : , (2009)
page : : 154 - 159
Abstract : Background: The anti-tumor effect of saffron extract has been proved in both in vitro and in vivo in recent years. In this study, cytotoxicity effect of total saffron extract on human liver carsinoma cells )HepG2( investigated in in vitro condition.Materials and methods: In this experimental study, the effects of total saffron extract on quantitative proliferation of all cell lines were determined by using 3-)4, 5-dimethyl thiazol-2yl( -2,5-diphenyl tetrazolium bromide )MTT( colorimetric assay. Also, effects of extract on mouse fibroblast cells )L929( were evaluated as the control. MTT assay is a fast, sensitive and quantitative method for all kind of cellعs proliferation by spectrophotometry. Amount of required extract for occurring 50percent cytotoxicity to the cells )IC 50( was achieved by administering different concentration of extract, and comparing the left alive cells with cells that no drug was used on them.Results: 50percent inhibition of tumor cells growth was achieved at 400 mg/ml. Extract had no inhibitory effect on normal cells growth.Conclusion: Total saffron extract can be used as cytotoxic agent against Cancer in vivo by producing cytoplasmic and nuclear changes.
Descriptor : SAFFRON EXTRACT
Descriptor : MTT ASSAY
Descriptor : L929 CELL LINE
Descriptor : HEPATOCARCINOMA
Descriptor : ANTI-TOMUR
Added Entry : TAVAKOL AFSHARI J
: RAKHSHANDEH HASAN
 
 
 
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