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library name : انستیتو تغذیه دانشگاه علوم پزشکی شهید بهشتی
Material Type : Latin Articles
Language of Document : English
Record Number : 61933
Doc. No : 588A
Main Entry : GHATREH SAMANI K
Title & Author : I405V AND -629C/A POLYMORPHISMS OF THE CHOLESTERYL ESTER TRANSFER PROTEIN GENE IN PATIENTS WITH CORONARY ARTERY DISEASE [Article]; HASHEMZADEH CHALESHTORI M.,FAROKHI EFAT,DARABI AMIN MASOUD
Title : IRANIAN BIOMEDICAL JOURNAL
Volume Number : , Vol.13 ؛ No.2
Date : , (2009)
page : : 103 - 108
Abstract : Background: Cholesteryl ester transfer protein )CETP( plays a main role in high-density lipoprotein metabolism. CETP gene possesses several single nucleotide polymorphisms which have been associated with plasma high-density lipoprotein cholesterol )HDL-C( concentrations. The aim of this study was to determine the association of CETP -629C/A and I405V polymorphisms with coronary artery disease )CAD( in Iranian population. Methods: The presence of two CETP gene polymorphisms -629C/A and I405V were studied in 187 unrelated CAD cases and 136 controls. All the samples were clinically examined and lipid profile was estimated. Genotyping was performed using polymerase chain reaction/restriction fragment length polymorphism method. Results: The frequency of -629C/A and I405V allelic variants were found to be 0.732 and 0.366 in cases and 0.658 and 0.348 in controls, respectively. The frequency of A allele of -629C/A polymorphism in cases was significantly higher than that of controls. HDL-C in AA genotype was higher than CA and CC genotypes in controls. No significant effect of II, IV and VV genotypes was found in lipid profiles. Conclusion: No significant association was found between CETP I405V polymorphism and increased risk of CAD in Azeri population studied. AA genotype of -629C/A increased HDL but the risk of CAD in this genotype might be higher than CC genotype.
Descriptor : CHOLESTERYL ESTER TRANSFER PROTEIN (CETP) GENE
Descriptor : I405V
Descriptor : HIGH-DENSITY LIPOPROTEIN (HDL) CHOLESTEROL
Descriptor : -629C/A
Added Entry : NOURI MOHAMMAD
: ROHBANI NOUBAR M
 
 
 
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