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library name : انستیتو تغذیه دانشگاه علوم پزشکی شهید بهشتی
Material Type : Latin Articles
Language of Document : English
Record Number : 61945
Doc. No : 600A
Call No : ‭Nut‬
Main Entry : KHADEMI R
Title & Author : IN VITRO EFFECT OF FOLIC ACID AND COBALAMIN (VITAMIN B12) ON ADHESION AND GROWTH OF GIARDIA LAMBLIA [Article]
Title : IRANIAN JOURNAL OF PARASITOLOGY
Volume Number : , Vol.1 ؛ No.1
Date : , (2006)
page : : 47 - 52
Abstract : Giardia lamblia is one of the most common intestinal protozoan parasites infecting human in the world. The goal of this study was searching for in-vitro effect of folic acid and cobalamin on adhesion and growth of G. lamblia as two important mechanisms in the pathogenesis in TYI-S-33 medium. G. lamblia trophozoites were obtained by in- vitro excystation procedure. Three groups of Giardia trophozoites were analyzed: control group, G.lamblia was cultured in TYI-S-33 without any vitamin, 2nd group with 0.1 mg/ml vitamin B12 or folic acid, and 3rd group with 0.5mg/ml of vitamin B12 or folic acid. All culture media tubes incubated at 37oC. After 2 h of incubation, the adherence into borosilicate culture tubes, and after 24 h the growth of trophozoites were measured .The results showed that in vitamin B12 groups, the growth was increased significantly )P آذ0.05( but the adherence decreased significantly )P آذ0.05(. Folic acid inhibited the growth rate significantly )P آذ0.05(, but it increased adherence in axenic culture significantly )P آذ0.05(. The results showed that vitamin B12 and folic acid altogether might reduce pathogenesis of G. lamblia by reducing adherence and growth, respectively.
Descriptor : GIARDIA LAMBLIA
Descriptor : COBALAMIN (VITAMIN B12)
Descriptor : FOLIC ACID
Added Entry : GHAFARIFAR F
: DALIMI ASL H.
 
 
 
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