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library name : انستیتو تغذیه دانشگاه علوم پزشکی شهید بهشتی
Material Type : Latin Articles
Language of Document : English
Record Number : 61946
Doc. No : 601A
Call No : ‭Nut‬
Main Entry : GHAFARI M.A
Title & Author : IN VITRO EFFECT OF -TOCOPHEROL, ASCORBIC ACID AND LYCOPENE ON LOW DENSITY LIPOPROTEIN GLYCATION [Article]
Title : IRANIAN JOURNAL OF PHARMACEUTICAL RESEARCH (IJPR)
Volume Number : , Vol.6 ؛ No.4
Date : , (2007)
page : : 265 - 271
Abstract : Nonenzymatic glycation of low density lipoprotein )LDL( is a reaction of glucose and other reducing sugars with apolipoprotein B100 )apo-B100( lysine residues. In diabetes, this reaction is greatly accelerated and is important in the pathogenesis of diabetic complications. The objective of this study was to investigate in vitro effects of a-tocopherol, ascorbic acid and lycopene on LDL glycation.LDL was isolated from EDTA-plasma by ultracentrifugation using a single step discontinuous gradient. LDL and glucose were incubated without and with different concentrations of lycopene, ascorbic acid and a-tocopherol. LDL glycation were estimated by sodium periodate assay.Based on this study results, a-tocopherol, ascorbic acid and lycopene decrease LDL glycation in a dose dependent manner. The electrophoretic mobility of glycated LDL decreased in presence these nutrients. These effects may be due to antioxidant properties of these nutrients and may have a role in ameliorating atherosclerotic risk of patients with diabetes mellitus.
Descriptor : LOW DENSITY LIPOPROTEIN (LDL)
Descriptor : GLYCATION
Descriptor : ?-TOCOPHEROL
Descriptor : ASCORBIC ACID
Descriptor : LYCOPENE
Added Entry : MOJAB S.
 
 
 
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