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library name : انستیتو تغذیه دانشگاه علوم پزشکی شهید بهشتی
Material Type : Latin Articles
Language of Document : English
Record Number : 61959
Doc. No : 614A
Main Entry : ESFAHANI ATA
Title & Author : INFLUENCE OF CHEMOTHERAPY ON THE OXIDANT/ANTIOXIDANT STATUS IN PATIENTS WITH ACUTE MYELOID LEUKEMIA [Article]; SANAAT Z.,GHORBANI HAGHJOU A.,RASHTCHIZADEH N.
Title : INTERNATIONAL JOURNAL OF HEMATOLOGY-ONCOLOGY AND STEM CELL RESEARCH (IJHOSCR)
Volume Number : , Vol.3 ؛ No.4
Date : , (2009)
page : : 3 - 4
Abstract : Background: Many of the chemotherapeutic agents used in patients with cancer cause to generate the enormous amounts of free radicals which may be associated with cell injury. In this study we aim to assess the effects of chemotherapy regimen on oxidant/antioxidant status in patients with acute myeloid leukemia.Material and Methods: 38 newly diagnosed patients with AML )44.7percent female and 55.3percent male( with mean age 34.05▒آ12.49 years were recruited in this study. All patients received Cytarabine at 100 mg/m لأآdaily by continuous infusion on days 1 through 7 and daunorubicin at 45 mg/m لأآon days 1 through 3 .Plasma levels of malondialdehyde )as indices of lipid per oxidation(, total antioxidant status )TAS(, and the levels of erythrocyte activity of superoxide dismutase )SOD( and glutathione peroxidase )GPx( were determined before chemotherapy and 14 days after chemotherapy with daunorubicin and cytarabine.Result: Plasma malondialdehyde )MDA( concentrations increased significantly )from 2.68▒آ0.89 nmol/ml to 3.14▒آ1.29 nmol/ml( during the 14 days postchemotherapy period )P=0.04(. Plasma TAS concentrations changed with chemotherapy from 1.09▒آ0.15 mmol/L to 1.02▒آ0.14 mmol/L with P=0.005. Erythrocyte SOD and GPX activity decreased overtime from 1157.24▒آ543.61 U/gHb to 984.01▒آ419.09 U/gHb )P=0.04( and 46.96▒آ13.70 U/gHb to 41.40▒آ6.44 U/gHb )P=0.02( respectively.Conclusions: In conclusion, we report here that there is an increase in MDA levels and a decrease in the levels of antioxidant enzymes and total antioxidant status. This suggests that chemotherapy causes these changes as a result of enormous production of reactive oxygen species in the patients with AML. Antioxidant supplementation must be approached with caution because of the probability of reduction the therapeutic efficacy of these cytotoxic drugs.
Descriptor : ACUTE MYELOID LEUKEMIA
Descriptor : CHEMOTHERAPY
Descriptor : OXIDATIVE STRESS
Descriptor : ANTIOXIDANT
Added Entry : GHOREYSHI Z
: NIKANFAR A
 
 
 
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