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library name : انستیتو تغذیه دانشگاه علوم پزشکی شهید بهشتی
Material Type : Latin Articles
Language of Document : English
Record Number : 61960
Doc. No : 616A
Main Entry : DANESHAMOUZ S.
Title & Author : INFLUENCE OF LIPOSOMES AND NIOSOMES ON THE IN VITRO PERMEATION AND SKIN RETENTION OF FINASTERIDE [Article]; JAFARI M.R.
Title : IRANIAN JOURNAL OF PHARMACEUTICAL SCIENCES
Volume Number : , Vol.1 ؛ No.3
Date : , (2005)
page : : 119 - 130
Abstract : In this work we sought to determine whether vesicles )liposomes/niosomes( were able to enhance finasteride concentration in the dermis layer, including the pilosebaceous units )PSU(. Such enhancement could be beneficial in the treatment of some androgen-related skin disorders. Hamster flank skin was used to study 3Hfinasteride permeation via vesicles and a hydroalcoholic solution )HA(. The drug-containing vesicles were composed of dimyristoyl phosphatidylcholine )DMPC( or egg lecithin: cholesterol: dicetyl phosphate )liposomes( and polyoxyethylene alkyl ethers )Brij آض‍series( or sorbitan monopalmitate )Span 40(: cholesterol: dicetyl phosphate )niosomes( and were prepared by the film hydration technique. Determination of finasteride content by HPLC showed 80-97percent drug entrapment efficiency in the vesicles. The amount of 3H-finasteride penetrated into and permeated through hamster skin 24 h after topical application of vesicles ranged from 5.5 to 13percent of the initial dose, compared to 24percent, observed with HA )p<0.05(. The amount of finasteride deposited within the different skin strata via gelstate Span 40 and lecithin vesicles was lower, when compared with liquid-state Brij97, Brij 76: Brij 97 and DMPC vesicles. The fraction of finasteride found in the dermis layer was greatest where DMPC liposomes were used )7.8percent(. The vesicles significantly reduced drug permeation as indicated by the flux of finasteride from vesicles )0.025-0.058إآ g/cm2.h(, where compared with the HA )0.13إآ g/cm2.h(, )p<0.01(. This study demonstrated the potentials of liquid-state vesicles in reducing the percutaneous absorption of finasteride and increasing its concentration and retention in the dermis layer.
Descriptor : DEPOSITION
Descriptor : DSC; FINASTERIDE
Descriptor : LIPOSOME
Descriptor : NIOSOME
Descriptor : PERMEATION
Added Entry : TABAKHIAN M.
: TAVAKOLI N.
 
 
 
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