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library name : انستیتو تغذیه دانشگاه علوم پزشکی شهید بهشتی
Material Type : Latin Articles
Language of Document : English
Record Number : 61972
Doc. No : 628A
Main Entry : KARIMZADEH P
Title & Author : INTRACTABLE SEIZURE DISORDERS: EFFICACY OF THE CLASSIC KETOGENIC DIET [Article]; TONEKABONI S.H.,GHOFRANI MOHSEN
Title : IRANIAN JOURNAL OF CHILD NEUROLOGY (IJCN)
Volume Number : , Vol.3 ؛ No.1
Date : , (2009)
page : : 15 - 20
Abstract : Objective: The ketogenic diet is a high-fat, low carbohydrate, adequate protein diet, developed in the 1920s for the management of intractable seizure disorders in children. To evaluate efficacy and tolerability of the classic ketogenic diet, we analyzed records of the children started on the diet from 1999 to 2006 at the Mofid childrenعs hospital.Materials & Methods: The subjects were 87 children, mean age 55 months. Before initiation of the diet, 55percent of the patients had seizures, at least 1-4 times per day, 36percent-5 or more per day and 9percent-2 to 4 times per week. Mean number of Anti Epileptic Drugs )AEDs( tried for them was 8 and 67percent were receiving three or more drugs.Results: The ketogenic diet showed drastic improvement, with at least 50percent reduction in seizure frequency in 87percent of our patients, 39percent of whom showed complete seizure control in the third month. After one year, in 80percent of the patients who returned, improvement continued, with 26percent of them being seizure free; besides, 23percent had one AED decreased, 36percent had two or three AEDs decreased, and 25percent )one child( had all AEDs discontinued. Of the 30 improved cases, 20percent, at the end of the first year, had improved behavior as well, and 23percent of them had become more alert. The medium diet duration of the improved group was 15 months.Conclusion: The improvement in our patients, low side effects, and the duration of diet by families reveal that the ketognic diet can still be a very useful alternative therapy in certain epileptic children.
Descriptor : SEIZURES
Descriptor : EPILEPSY
Descriptor : DIET
Descriptor : KETOGENIC
Added Entry : TABARESTANI S
: MAHVELATI SHAMSABADI F
 
 
 
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