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library name : انستیتو تغذیه دانشگاه علوم پزشکی شهید بهشتی
Material Type : Latin Articles
Language of Document : English
Record Number : 61979
Doc. No : 635A
Main Entry : REZAEI MOHSEN
Title & Author : INVOLVEMENT OF SUBCELLULAR ORGANELLES IN INFLAMMATORY PAIN-INDUCED OXIDATIVE STRESS AND APOPTOSIS IN THE RAT HEPATOCYTES [Article]; POURAHMAD J
Title : ARCHIVES OF IRANIAN MEDICINE
Volume Number : , Vol.11 ؛ No.4
Date : , (2008)
page : : 407 - 417
Abstract : Background: Subcutaneous injection of formalin in the plantar surface of ratعs hind paw is frequently used as an animal model to study pain associated with inflammation. The pain produced by formalin test differs significantly from that of acute nociceptive tests. In this study, we first investigated the cellular and molecular mechanisms responsible for chronic inflammatory paininduced damage in the rat hepatocytes and finally we tried to figure out whether both selective)celecoxib( and nonselective )acetylsalicylic acid( cyclo-oxygenase inhibitors could protecthepatocytes against pain-induced damage.Methods: The male Wistar rats were divided in one-, four-, and seven-day pain groups. Twentyfour hours prior to pain induction with subcutaneous injection of 5percent formalin into the hind paw, acetylsalicylic acid or celecoxib was administered to the animals of similar one-, four-, and sevenday pain groups. A no-pain )control( group was also considered for each of the experiments.Results: Our results showed a significant rise in both formation of reactive oxygen species and collapse in the mitochondrial membrane potential )percentDym( in all pain groups )P<0.05(. Significant lysosomal membrane damage and hepatocyte proteolysis were only seen in one-and four-day pain groups )P<0.05(. Caspase 3 activity also showed a significant )P<0.05( rise in all three pain groups. Conclusion: Formation of reactive oxygen species and mitochondrial/lysosomal damages were significantly inhibited by both acetylsalicylic acid and celecoxib in hepatocytes of all painsuffering animals. Nonetheless, celecoxibعs tendency to raise caspase 3 activities, suggested that it accelerates the apoptosis in hepatocytes of pain-suffering animals. Our results showed that the pain per se, could initiate some harmful signals that affect other cells other than neurons; these malicious signals could be magnified by use of some analgesics particularly selective yclooxygenase inhibitors.
Descriptor : HEPATOCYTE
Descriptor : INFLAMMATION
Descriptor : LYSOSOME
Descriptor : MITOCHONDRIA
Descriptor : PAIN
Added Entry : RASEKH H.R
: AHMADIANI A.A.H
 
 
 
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