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library name : انستیتو تغذیه دانشگاه علوم پزشکی شهید بهشتی
Material Type : Latin Articles
Language of Document : English
Record Number : 62004
Doc. No : 662A
Main Entry : KAZEROUNI F.,
Title & Author : LDL SUBCLASS PATTERNS AND ATHEROGENICITY IN NON-INSULIN DEPENDENT DIABETES MELLITUS [Article]; ARDESHIR LARIJANI MOHAMMAD BAGHER
Title : ACTA MEDICA IRANICA
Volume Number : , Vol.42 ؛ No.5
Date : , (2004)
page : : 325 - 330
Abstract : Low density lipoprotein )LDL( subclass pattern B is characterized by predominance of small dense LDL. Subjects with pattern B tend to have higher triglyceride )TG( and lower levels of high density lipoprotein cholesterol )HDL-C(. Small dense LDL is associated with increased risk of coronary disease. In this study, effect of non-insulin dependent diabetes mellitus )NIDDM( on LDL size, plasma TG and HDL-C were assessed in Iranian patients. LDL size was determined by non-denaturing gradient polyacrylamide gel electrophoresis in 81 NIDDM and 81 healthy subjects )age 50 to 70 yrs(. TG and HDL-C were measured by analytical kits. Fifty nine percent of diabetics and 27percent of controls showed LDL pattern B. LDL size was significantly lower in diabetics than controls )25.1 ▒آ1.5 vs 25.8 ▒آ2.8 nm, P<0.001(. Diabetics had significantly higher triglyceride than controls )187.8 ▒آ 90 vs 145.6 ▒آ 69 mg/dl, P<0.001( and lower HDL-C )47.5 ▒آ12 vs 57.1 ▒آ14 mg/dl, P<0.001(. LDL size correlated negatively with TG )r = -0.281, P<0.05(. Diabetics showed 2-fold increase in frequency of pattern B which may explain increased risk of coronary disease in these patients.
Descriptor : SMALL DENSE LOW DENSITY LIPOPROTEIN
Descriptor : PATTERN B
Descriptor : TRIGLYC
Added Entry : JAVADI1 E
: DOUSTI M.,
 
 
 
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