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library name : انستیتو تغذیه دانشگاه علوم پزشکی شهید بهشتی
Material Type : Latin Articles
Language of Document : English
Record Number : 62012
Doc. No : 670A
Main Entry : MOVAHEDIAN AHMAD
Title & Author : LIPID LOWERING EFFECT OF ETHANOLIC EXTRACT OF AERIAL PARTS OF PEUCEDANUM PASTINACIFOLIUM BOISS. AND HAUSSKN. IN HYPERCHOLESTEROLEMIC RATS [Article]
Title : IRANIAN JOURNAL OF PHARMACEUTICAL RESEARCH (IJPR)
Volume Number : , Vol.8 ؛ No.4
Date : , (2009)
page : : 301 - 306
Abstract : Increased plasma cholesterol is known to be a major risk related to the development of coronary artery disease. The main purpose of this study was to detennine possible effects of the ethanolic extract of aerial parts of Peucedanumpastinacifolium on the serum lipids in hypercholesterolemic rats. Experimental hypercholesterolemiawas induced by feeding rats a cholesterol-enriched diet for 56 days. Hypercholesterolemic rats were classified into five groups. One group did not receive treatments and served as a control hypercholesterolemic group. The other four groups were fed the cholesterol-enriched diet in conjunction with 125, 250, 500 mg extract per kg of the body weight along with 20 mg atrovaststin per kg body weight, in a daily oral dose. A normal group of rats fed with a plain chow diet was also included in the study.After oral administrationfor 8 weeks,P pastinactfolium extract produced significantdecrease on serumtotal cholesterol, low-densitylipoprotein cholesterol, triglyceride levels and atherogenic indices in hypercholesterolemicgroups )P<0.05(. P.pastinactfolium extract had no effects on serum high-density lipoproteincholesterol levels in these groups. It is concluded that the extract of aerial parts of P.pastinacifolium exhibits lipid lowering activity in hypercholesterolemic rats. However, further investigationwould be necessary to evaluate the mechanism of action of the extract.
Descriptor : PEUCEDANUM PASTINACLFOLIUM
Descriptor : LIPOPROTEINS
Descriptor : CHOLESTEROL
Descriptor : HYPERCHOLESTEROLEMIA
Added Entry : SAJADI S.E
: AHMADI MAHDI
 
 
 
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