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library name : انستیتو تغذیه دانشگاه علوم پزشکی شهید بهشتی
Material Type : Latin Articles
Language of Document : English
Record Number : 62030
Doc. No : 689A
Main Entry : MOSHTAGHI SEYED ALI ASGHAR
Title & Author : MANGANESE AND IRON BINDING TO HUMAN TRANSFERRIN [Article]
Title : IRANIAN JOURNAL OF PHARMACEUTICAL RESEARCH (IJPR)
Volume Number : , Vol.6 ؛ No.2
Date : , (2007)
page : : 101 - 106
Abstract : The characteristics of manganese and iron binding to human apotransferrin )apo-tf( have been investigated and compared in this study. Both metal ions were taken up by human apo-tf and formed complexes, with the maximum absorbances observed at 410 and 340 nm for manganese-transferrin )Mn-tf( and 465 nm for iron-transferrin )Fe-tf(. Addition of manganese )1.5 mg/ml( to the reaction mixture containing iron and apo-tf, reduced Fe binding to apo-tf by 20 percent, in comparison to the control sample. The binding of both metals to apo-tf appears to be time and pH dependent processes.Using the equilibrium dialysis technique, the binding constant of manganese to apo-tf was also determined. The binding constant of Mn to apo-tf was calculated, using the Scatchard plot analysis. The calculated Ka was 3.1أ109 M-1.The binding of manganese and iron to human apo-tf has been discussed and compared in this work, using different biochemical techniques.
Descriptor : MANGANESE
Descriptor : IRON
Descriptor : TRANSFERRIN
Descriptor : BINDING ACTIVITY
Added Entry : BADIEI AKBAR
 
 
 
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