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library name : انستیتو تغذیه دانشگاه علوم پزشکی شهید بهشتی
Material Type : Latin Articles
Language of Document : English
Record Number : 62033
Doc. No : 692A
Main Entry : ASADPOUR PIRANFAR M
Title & Author : MEASUREMENT OF OXIDIZED LOW-DENSITY LIPOPROTEIN AND SUPEROXIDE DISMUTASE ACTIVITY IN PATIENTS WITH HYPERTENSION [Article]
Title : ARCHIVES OF IRANIAN MEDICINE
Volume Number : , Vol.12 ؛ No.2
Date : , (2009)
page : : 116 - 120
Abstract : Background: Arterial hypertension is an important risk factor for coronary artery disease and cardiovascular-induced morbidity and mortality. It can cause end-organ damages such as cerebrovascular diseases, renal failure, and congestive heart failure. On the other hand, because of elevated blood pressure and rapid blood flow, there is an increase in oxidation and peroxidation reactions. The aim of this study was to evaluate the level of oxidized low-density lipoprotein and superoxide dismutase activity in sera of hypertensive patients.Methods: In this case-control study, 70 hypertensive patients without any other important diseases such as congestive heart failure, cardiomyopathy, liver disease, diabetes mellitus, renal disease, or thyroid disease were compared with 70 age-and gender-matched controls. The participants' age range was from 30 to 75 years. Measurement of oxidized low-density lipoprotein in serum was performed by enzyme-linked immunosorbent assay. The activity of superoxide dismutase in serum was measured by enzymatic colorimetry method. Results: The patients' mean age▒آSD was 52.2▒آ14 years. The controls' mean age▒آSD was 45▒آ13 years. The level of superoxide dismutase activity in the patients' group was 100▒آ27 U/mL, and in the controls عgroup was 105▒آ11 U/mL. The level of oxidized low-density lipoprotein in the patients' group was 14▒آ4 mu/L, and in controls it was 7.7▒آ3 mu/L. Conclusion: Data of this study demonstrated an elevation of oxidized low -density lipoprotein in hypertensive group that may be the result of oxidation processes. Superoxide dismutase activity was decreased in hypertensive patients, which can be the result of elevated oxidation reactions.
Descriptor : HYPERTENSION
Descriptor : OXIDIZED LDL
Descriptor : SUPEROXIDE DISMUTASE
Added Entry : PORDAL A.H
: BEYRANVAND M.R
 
 
 
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