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library name : انستیتو تغذیه دانشگاه علوم پزشکی شهید بهشتی
Material Type : Latin Articles
Language of Document : English
Record Number : 62039
Doc. No : 698A
Main Entry : JANAHMADI M.
Title & Author : MODIFICATION OF NIFEDIPINE INHIBITORY EFFECT ON CALCIUM SPIKE AND LTYPE CALCIUM CURRENT BY ETHANOL IN F1 NEURON OF HELIX ASPERSA [Article]
Title : IRANIAN BIOMEDICAL JOURNAL
Volume Number : , Vol.7 ؛ No.3
Date : , (2003)
page : : 99 - 106
Abstract : There is strong evidence demonstrating that nifedipine dissolved in ethanol selectivelyع‌ژ inhibits only L-type Ca +2urrent. In addition, acute ethanol exposure reducesع‌ژ voltage-dependent calcium currents. In the present study, we investigated theع‌ژ antagonistic effect of fixed concentration of nifedipine dissolved in differentع‌ژ concentration of ethanol on L-type Ca +2urrent. In a Na +-+ree solution,ع‌ژ nifedipine dissolved in 60 and 120 mM ethanol decreased resting membrane potentialع‌ژ of Ca +2pikes and caused a significant reduction in amplitude, duration and anع‌ژ increase in threshold of Ca +2pikes. Furthermore, Ca +2urrent was inhibited byع‌ژ ethanol in a concentration-dependent manner, so that the reduction of L-type Ca+ ع‌ژ2urrent by nifedipine/60 and 120 mM ethanol was statistically significant. Meanwhile;ع‌ژ ethanol concentration-dependent response of Ca2+ currents was observed at its lateع‌ژ component in more positive potentials. These results may be consistent with ethanolع‌ژ-dependent inhibition of L-type Ca +2urrents and ethanol-dependent enhancement ofع‌ژ a Ca-+2ctivated potassium current.ع‌ع
Descriptor : ETHANOL
Descriptor : NIFEDIPINE
Descriptor : CA+ SPIKES
Descriptor : L-TYPE CA+ CURRENT
Descriptor : F1 NEURON
 
 
 
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