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library name : انستیتو تغذیه دانشگاه علوم پزشکی شهید بهشتی
Material Type : Latin Articles
Language of Document : English
Record Number : 62089
Doc. No : 750A
Main Entry : JENABI A
Title & Author : PENTOXIFYLLINE CAN IMPROVE ANEMIA OF HEMODIALYSIS PATIENTS VIA OVERCOMING IRON RETICULOENDOTHELIAL BLOCKADE (ORAL PRESENTATIONS: O101) [Article]; MORAKI A.,BROUMAND B.
Title : IRANIAN JOURNAL OF KIDNEY DISEASES (IJKD)
Volume Number : , Vol.3 ؛ No.SUPPLEMENT 1
Date : , (2009)
page : : 2 - 2
Abstract : Introduction. Chronic inflammation is one of the etiologies of inadequate response to erythropoetin in treatment of anemia of chronic hemodialysis patients. Reticuloendothelial blockade that is clinically expressed by high serum ferritin level )> 800 ng/ml( and low serum iron and trasferrin saturation test )TSAT; < 25percent( inspite of iron supplementation is the well known mechanism of causing anemia in these patients. Pentoxifylline, a methyl xanthine derivative used for treatment of peripheral vascular disease has been found to have anti-inflammatory properties due to many cytokines inhibition. We hypothesized that pentoxifylline, because of anti-inflammatory effects, overcomes iron reticuloendothelial blockade and improves anemia of chronic hemodialysis patients. Methods. In 110 patients )M/F = 52/58( from the three hemodialysis centers of Tehran, we found 15 patients )13.6percent; M/F = 6/9( who displayed elevated ferritin level )> 800 ng/ml( and TSAT < 25percent as defined. They received pentoxifylline with the dose of 400mg twice daily for two months. At beginning, baseline levels of hemoglobin, hematocrit, and serum iron, TIBC, ferritin, and TSAT were recorded and then measurements were repeated after 2 months.Results. At the end of the study, pentoxifylline increased hemoglobin level in 13 of 15 patients )11.7▒آ1.87 vs. 9.8 ▒آ 1.23 g/dl, P < 0.002(. Ferritin values markedly decreased after treatment )849▒آ586.7 vs. 1139▒آ673.3 ng/ml, P<0.003(. Serum iron also increased )66.8 ▒آ 28.6 vs. 51 ▒آ18.52 mg/dl, P < 0.03(. Finally, transferring saturation ratio increased in 11 patients. Mean TSAT values increased )23.3▒آ7.87 vs. 16.4▒آ5.2 percent, P<0.004( at the end of study. Conclusion. This study indicates that pentoxifylline, as an anti-inflammatory drug, can improve anemia of hemodialysis patients by correcting reticuloendothelial blockade of iron.
Descriptor : PECTIC ACID
Descriptor : PROLACTIN
Descriptor : PITUITARY
Descriptor : GH3/B6 CELLS
Added Entry : SHALCHIAN Z
: JABARI M
 
 
 
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