خط مشی دسترسیدرباره ما
ثبت نامثبت نام
راهنماراهنما
فارسی
ورودورود
صفحه اصلیصفحه اصلی
جستجوی مدارک
تمام متن
منابع دیجیتالی
رکورد قبلیرکورد بعدی
library name : انستیتو تغذیه دانشگاه علوم پزشکی شهید بهشتی
Material Type : Latin Articles
Language of Document : English
Record Number : 62090
Doc. No : 751A
Main Entry : MOHITI ARDAKANI J
Title & Author : PERCENTAGE OF FREE TO TOTAL LEPTIN IN DIABETIC PATIENTS AND ITS CORRELATION TO BLOOD INSULIN, GLUCOSE AND LIPIDS [Article]
Title : IRANIAN JOURNAL OF DIABETES AND OBESITY
Volume Number : , Vol.1 ؛ No.1
Date : , (2009)
page : : 16 - 21
Abstract : INTRODUCTION: Leptin is a hormone resulting from the obesity gene which could be important in the pathogenesis of the insulin. Only limited data concerning the interaction of insulin, glucose tolerance and free leptin are available and no data exist on the potential influence of free vs. bound circulating leptin. We, therefore, studied percentage of free to total leptin in diabetic patients.MATERIAL AND METHODS: Thirty non-insulin dependent diabetic obese patients )age: 50▒آ20 years, BMI >30 kg/m (لأآand 30 non-insulin dependent diabetic non-obese patients )age: 50▒آ20 years, BMI <25 kg/m (لأآwere studied. Free leptin was purified by Gel filtration chromatography and the fractions were collected and then their free leptin was measured by a high sensitive ELISA method. Circulation total leptin and insulin was measured by ELISA.RESULTS: Circulation total leptin was significantly correlated to insulin )P<0.005(. Percentage of free leptin to total in obese subjects was more than non-obese subjects )27percent▒آpercent1 vs. percent3▒آpercent4, [P<0.001[(. Percentage of free to total leptin showed a positive correlation with insulin )r=0.58 [P<0.001[(, insulin resistance )r=31 [P<0.015[( and BMI )r=0.86 [P<0.001[(. CONCLUSION: The majority of leptin which circulates in obese individuals was free form. Presumably it is bioactive protein of hormone and thus obese subjects are resistant to free leptin.
Descriptor : PERCENT OF FREE TO TOTAL LEPTIN
Descriptor : INSULIN
Descriptor : DIABETES INTRODUCTION: Leptin is a hormone resulting from the obesity gene which could be important in the pathogenesis of the insulin. Only limited data concerning the interaction of insulin
Descriptor : glucose tolerance and free leptin are available and no data exist on the potential influence of free vs. bound circulating leptin. We
Descriptor : therefore
Descriptor : studied percentage of free to total leptin in diabetic patients.MATERIAL AND METHODS: Thirty non-insulin dependent diabetic obese patients (age: 50▒آ20 years
Descriptor : BMI >30 kg/m(لأآ and 30 non-insulin dependent diabetic non-obese patients (age: 50▒آ20 years
Descriptor : BMI <25 kg/m(لأآ were studied. Free leptin was purified by Gel filtration chromatography and the fractions were collected and then their free leptin was measured by a high sensitive ELISA method. Circulation total leptin and insulin was measured by ELISA.RESULTS: Circulation total leptin was significantly correlated to insulin (P<0.005). Percentage of free leptin to total in obese subjects was more than non-obese subjects (27
Descriptor : ▒آ
Descriptor : 1 vs.
Descriptor : 3▒آ
Descriptor : 4
Descriptor : [P<0.001]). Percentage of free to total leptin showed a positive correlation with insulin (r=0.58 [P<0.001])
 
 
 
(در صورت عدم وضوح تصویر اینجا را کلیک نمایید)