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library name : انستیتو تغذیه دانشگاه علوم پزشکی شهید بهشتی
Material Type : Latin Articles
Language of Document : English
Record Number : 62105
Doc. No : 766A
Main Entry : DEHGHAN M.H.
Title & Author : PLASMA LEVEL OF VITAMIN C IN WOMEN WITH PRE-ECLAMPSIA IN ARDABIL, IRAN [Article]
Title : IRANIAN JOURNAL OF REPRODUCTIVE MEDICINE
Volume Number : , Vol.4 ؛ No.1
Date : , (2006)
page : : 35 - 39
Abstract : Background: Pre-eclampsia, a vascular disorder of pregnancy, is a leading cause of maternal morbidity as well as perinatal morbidity and mortality. The cause of pre-eclampsia remains largely unknown. Accumulating evidences from clinical and epidemiological studies suggest that diffuse endothelial dysfunction, resulting from oxidative stress, plays an important role in the pathogenesis of pre-eclampsia. Independent effect of maternal biological markers, such as elevated triglyceride or low plasma vitamin C )ascorbic acid( concentrations are related to increased pre-eclampsia risk.Objectives: The aim of this study was to determine plasma concentrations of vitamin C in women with pre-eclampsia.Materials and Methods: This cross-sectional, case controlled study comprises 40 pre-eclamptic and 80 normo-tensive pregnant women of singleton gestations in third trimester, in Allavi Hospital, Ardabil, Iran. Blood samples )5ml( were collected aseptically in heparin tube, and the plasma concentration of vitamin C was determined by spectrophotometric method . SPSS software package was used for analyzing the data.Results: Plasma vitamin C level was found to be significantly lower )p<0.001( in the pre-eclampsia group than this level in the control group. Vitamin C levels in the pre-eclampsia group were found to be influenced by their maternal age )p<0.01(, and was positively related to the gestational age )p<0.01(.Conclusion: Knowledge from this study may contribute to the development and evaluation of behavioral and medical interventions aimed at reducing the occurrence of pre-eclampsia.
Descriptor : PRE-ECLAMPSIA
Descriptor : PREGNANCY
Descriptor : VITAMIN C
Added Entry : DEHGHANAN R.
 
 
 
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