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library name : انستیتو تغذیه دانشگاه علوم پزشکی شهید بهشتی
Material Type : Latin Articles
Language of Document : English
Record Number : 62147
Doc. No : 808A
Main Entry : DURAIRAJ A
Title & Author : PROTECTIVE ACTIVITY AND ANTIOXIDANT POTENTIAL OF LIPPIA NODIFLORA EXTRACT IN PARACETAMOL INDUCED HEPATOTOXICITY IN RATS [Article]; MALAYA G.
Title : IRANIAN JOURNAL OF PHARMACOLOGY AND THERAPEUTICS (IJPT)
Volume Number : , Vol.7 ؛ No.1
Date : , (2008)
page : : 83 - 89
Abstract : This study was designed to evaluate the hepatoprotective and antioxidant activity of methanol extract of Lippia nodiflora )MELN( in acute experimental liver injury induced by paracetamol )750mg/kg, b.w(. MELN at the doses of 200 and 400mg/kg, p.o was administered for 7 days and biochemical parameters such as serum glutamate oxaloacetate transaminase )SGOT(, glutamate pyruvate transaminase )SGPT(, alkaline phosphatase )ALP(, bilirubin and total proteins with enzymatic and non-enzymatic antioxidant level were recorded. MELN at both doses prevented the increase in liver weight when compared to hepatotoxin treated control. The higher dose )400 mg/kg( of Lippia nodiflora extract was found to be more effective than the lower dose )200 mg/kg( in paracetamol induced liver damage. MELN produced significant )p<0.001( hepatoprotective effect by decreasing the activity of serum enzymes such as SGOT, SGPT, ALP, bilirubin and lipid peroxidation while it significantly )p<0.001( increased the levels of total proteins, glutathione )GSH(, catalase )CAT( and superoxide dismutase )SOD( in a dose dependent manner. The activity of MELN was compared with standard drug silymarin )25mg/kg(, which is a well-known natural anti-hepatotoxic drug and the potency of MELN is more or less the same as that of silymarin. It is con-cluded that the methanol extract of whole plant possesses good hepatoprotective activity probably by its antioxidative potential on hepatocytes.
Descriptor : ANTIOXIDANT ESTIMATION
Descriptor : BIOCHEMICAL ANALYSIS
Descriptor : HEPATOPROTECTIVE
Descriptor : HEPATOTOXICITY
Descriptor : LIPPIA NODI-FLORA
Descriptor : PARACETAMOL
Descriptor : RATS
Added Entry : VAIYAPURI T.S
: KANTI M.U
 
 
 
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